Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease.

In conclusion, palmitate appear to up-regulate PPARγ via PGC1α in Huh7 cells, and both PGC1α and PPARγ are up-regulated in the NAFLD mice liver, suggesting an effect on lipid metabolism leading to intrahepatic triglyceride accumulation. PMID: 26941577 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/26941577?dopt=Abstract

Source: International Journal of Medical Sciences - March 6, 2016 Category: Biomedical Science Tags: Int J Med Sci Source Type: research