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Nutrition: Vitamin A
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Total 327 results found since Jan 2013.
Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain
AbstractThe cytochrome P450 proteins (CYP450s) have been implicated in catalyzing numerous important biological reactions and contribute to a variety of diseases. CYP26A1, a member of the CYP450 family, carries out the oxidative metabolism of retinoic acid (RA), the active metabolite of vitamin A. Here we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation (SNL). CYP26A1 was mainly expressed in spinal neurons and astrocytes. HPLC analysis displayed that the content of all-trans-RA (at-RA), the substrate of CYP26A1, was reduced in the spinal cord on day 7 after SNL. Inhibition of ...
Source: Neuroscience Bulletin - August 28, 2023 Category: Neuroscience Source Type: research
Palmitic acid promotes human retinal pigment epithelial cells migration by upregulating miR-222 expression and inhibiting NUMB
This study unravels a novel PA-miR-222-NUMB axis that can be potentially targeted for therapy of high fat acid-related ocular diseases.PMID:37566749 | DOI:10.18632/aging.204647
Source: Aging - August 11, 2023 Category: Biomedical Science Authors: Fengzhi Li Chunling Lei Ke Gong Shuwei Bai Lianyi Sun Source Type: research
Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells
In this study, we hypothesized that semaphorin 7a (Sema7a) was involved in the increased inflammatory mediators and permeability changes in retinal endothelial cells (REC) grown in high glucose. For these studies, we used diabetic mouse samples and REC to investigate our hypothesis. Primary retinal endothelial cells were grown in normal (5 mM) or high glucose (25 mM glucose) for measurements. In a subset of cells grown in high glucose, cells were transfected with Sema7a siRNA or scrambled siRNA. We measured levels of key inflammatory mediators and zonula occludens-1 (ZO-1) and occludin levels by Western blot. Data suggest ...
Source: Cell Research - July 15, 2023 Category: Cytology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research
ATRA ameliorates fibrosis by suppressing the pro-fibrotic molecule Fra2/AP-1 in systemic sclerosis
In this study, the pro-fibrotic effect of Fra2 in SSc is confirmed. SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc animals exhibit increased levels of Fra2. Inhibition of Fra2 expression in SSc dermal fibroblasts with Fra2 siRNA markedly decreased collagen I expression. ATRA reduced the expressions of Fra2, collagen I, and α-smooth muscle actin(α-SMA) in SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc mice. In addition, chromatin immunoprecipitation and dual-luciferase assays demonstrated that retinoic acid receptor RARα binds to the FRA2 promoter and modulates its transcriptio...
Source: International Immunopharmacology - June 18, 2023 Category: Allergy & Immunology Authors: Zixin Pi Jiani Liu Yangfan Xiao Xinglan He Ruixuan Zhu Rui Tang Xiangning Qiu Yi Zhan Zhuotong Zeng Yaqian Shi Rong Xiao Source Type: research
Evaluation of the role of Sigma 1 receptor and Cullin3 in retinal photoreceptor cells
Free Radic Biol Med. 2023 Jun 14:S0891-5849(23)00496-3. doi: 10.1016/j.freeradbiomed.2023.06.010. Online ahead of print.ABSTRACTSigma 1 receptor (Sig1R), a pluripotent modulator of cell survival, is neuroprotective in models of retinal degeneration when activated by the high-affinity, high-specificity ligand (+)-pentazocine ((+)-PTZ). The molecular mechanisms of Sig1R-mediated retinal neuroprotection are under investigation. We previously reported that the antioxidant regulatory transcription factor Nrf2 may be involved in Sig1R-mediated retinal photoreceptor cell (PRC) rescue. Cullin 3 (Cul3) is a component of the Nrf2-Ke...
Source: Free Radical Biology and Medicine - June 16, 2023 Category: Biology Authors: Jing Wang Shannon R Barwick Haiyan Xiao Sylvia B Smith Source Type: research
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity
ConclusionIn conclusion, our study clarifies the presence of RFC1 protein in the inner BRB, which has recently been defined as hypoxia –immune-related gene in other tissues and offers a novel perspective of retinal RFC1. Hence, other than being a folate carrier, RFC1 is an acute regulator of the inner BRB in healthy and ischemic retinas.
Source: Fluids and Barriers of the CNS - June 16, 2023 Category: Neuroscience Source Type: research
Mechanisms of MALAT1 regulating proliferative diabetic retinopathy via targeting miR-126-5p
CONCLUSIONS: MALAT1 promotes PDR by inhibiting miR126-5p and inducing REC proliferation, migration and angiogenesis.PMID:37303661 | PMC:PMC10251023
Source: American Journal of Translational Research - June 12, 2023 Category: Research Authors: Wei Zhao Yanli Liu Cairui Li Zhijian Yin Yi Liu Meixia An Source Type: research
