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Nutrition: Vitamin A
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Total 327 results found since Jan 2013.
Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes.
CONCLUSIONS: These results suggest that VA-lip-siRNA HSP47 improves pulmonary fibrosis in not only preventive, but also therapeutic schedules, and thus, this drug delivery system should provide a novel therapy for refractory pulmonary fibrosis.
PMID: 29035148 [PubMed - as supplied by publisher]
Source: Experimental Lung Research - October 17, 2017 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research
Inhibition of BMP4 and Alpha Smooth Muscle Actin Expression in LX-2 Hepatic Stellate Cells by BMP4-siRNA Lipid Based Nanoparticle.
Conclusion: VA-coated liposomes were successfully designed to deliver BMP4-siRNA to specifically target HSC. The novel delivery system discussed herein may serve as a potential therapeutic strategy for the treatment of liver fibrosis in the future. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
PMID: 29578859 [PubMed - in process]
Source: J Pharm Pharm Sci - March 28, 2018 Category: Drugs & Pharmacology Authors: Omar R, Yang J, Alrushaid S, Burczynski FJ, Minuk GY, Gong Y Tags: J Pharm Pharm Sci Source Type: research
Molecules, Vol. 28, Pages 3318: A Straightforward Method for the Development of Positively Charged Gold Nanoparticle-Based Vectors for Effective siRNA Delivery
tr I. Nikitin
The therapeutic potential of short interfering RNA (siRNA) to treat many diseases that are incurable with traditional preparations is limited by the extensive metabolism of serum nucleases, low permeability through biological membrane barriers because of a negative charge, and endosomal trapping. Effective delivery vectors are required to overcome these challenges without causing unwanted side effects. Here, we present a relatively simple synthetic protocol to obtain positively charged gold nanoparticles (AuNPs) with narrow size distribution and the surface modified with Tat-related cell-penetrating pepti...
Source: Molecules - April 8, 2023 Category: Chemistry Authors: Tatiana N. Elizarova Maxim L. Antopolsky Denis O. Novichikhin Artemiy M. Skirda Alexey V. Orlov Vera A. Bragina Petr I. Nikitin Tags: Article Source Type: research
Retinol-binding protein-hijacking nanopolyplex delivering siRNA to cytoplasm of hepatic stellate cell for liver fibrosis alleviation
This study provides a sophisticated method for HSC-targeting cytoplasmic RNA delivery using endogenous ligand hijacking and dual sensitivity of ROS and cis diol compounds.PMID:37167895 | DOI:10.1016/j.biomaterials.2023.122134
Source: Biomaterials - May 11, 2023 Category: Materials Science Authors: Jinsheng Huang Huiling Huang Yiyao Wang Bin Xu Minzhao Lin Shisong Han Yuanyuan Yuan Yong Wang Xintao Shuai Source Type: research
Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes
Conclusion
These data suggest the therapeutic potential of the present approach for reversing pancreatic fibrosis.
Source: Gut - August 5, 2013 Category: Gastroenterology Authors: Ishiwatari, H., Sato, Y., Murase, K., Yoneda, A., Fujita, R., Nishita, H., Birukawa, N. K., Hayashi, T., Sato, T., Miyanishi, K., Takimoto, R., Kobune, M., Ota, S., Kimura, Y., Hirata, K., Kato, J., Niitsu, Y. Tags: Cirrhosis, Pancreas and biliary tract, Pancreatitis, Editor's choice Source Type: research
Development of a Peptide-Modified siRNA Nanocomplex for Hepatic Stellate Cells
Publication date: Available online 7 September 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Zhen Zhao, Yuanke Li, Akshay Jain, Zhijin Chen, Hao Liu, Wei Jin, Kun Cheng Insulin-like growth factor 2 receptor (IGF2R) is overexpressed in activated Hepatic stellate cells (HSCs) and therefore can be utilized for HSC-specific drug delivery. We recently discovered an IGF2R-specific peptide using a novel biopanning. Here, we adopted biotin-conjugated IGF2R-specific peptide, cholesterol, and vitamin A as the targeting ligands for the neutravidin-based siRNA nanocomplex to deliver PCBP2 siRNA, a potentia...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - September 8, 2017 Category: Nanotechnology Source Type: research
Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease
Chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (SCT) is characterized by multiorgan fibrosis and profoundly affects the quality of life of transplant survivors. Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, plays a critical role in collagen synthesis in myofibroblasts. We explored the role of HSP47 in the fibrotic process of cutaneous chronic GVHD in mice. Immunohistochemical analysis showed massive fibrosis with elevated amounts of collagen deposits and accumulation of F4/80+ macrophages, as well as myofibroblasts expressing HSP47 and retinol-bin...
Source: Blood - March 29, 2018 Category: Hematology Authors: Yamakawa, T., Ohigashi, H., Hashimoto, D., Hayase, E., Takahashi, S., Miyazaki, M., Minomi, K., Onozawa, M., Niitsu, Y., Teshima, T. Tags: Transplantation Source Type: research
SiRNA silencing of VEGF, IGFs, and their receptors in human retinal microvascular endothelial cells.
Authors: Nicolau Y, Bany-Mohammed F, Cai CL, Aranda JV, Beharry KD
Abstract
Vascular endothelial growth factor (VEGF) is a potent mitogen that regulates proliferation, migration, and tube formation of endothelial cells (EC). VEGF has recently become a target for severe retinopathy of prematurity (ROP) therapy. We tested the hypothesis that a specific VEGF isoform and/or receptor acts synergistically with insulin-like growth factor (IGF)-I to alter normal retinal microvascular EC angiogenesis and RNA interference can be used to reverse VEGF effects. We used small interfering RNA (SiRNA) transfection to target VEGF i...
Source: American Journal of Translational Research - August 11, 2018 Category: Research Tags: Am J Transl Res Source Type: research
Ocular Instillation of Vitamin A-Coupled Liposomes Containing HSP47 siRNA Ameliorates Dry Eye Syndrome in Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (GVHD) is characterized by multiorgan fibrosis and affects the quality of life of transplant survivors. Ocular manifestations are found in 40-60% of GVHD patients, and the most common symptom is dry eye syndrome associated with lacrimal gland fibrosis. We previously demonstrated heat shock protein 47 (HSP47), a collagen specific molecular chaperone, plays a critical role in excessive collagen synthesis in chronic GVHD, and systemic administration of vitamin A-coupled liposomes carrying HSP47 siRNA (VA-lip HSP47) ameliorates skin and salivary gland fibrosis in chronic GVHD (Yamakawa, et al, Blood 2018).
Source: Biology of Blood and Marrow Transplantation - January 31, 2019 Category: Hematology Authors: Hiroyuki Ohigashi, Daigo Hashimoto, Shuichiro Takahashi, Tomohiro Yamakawa, Eiko Hayase, Takanori Teshima Tags: 229 Source Type: research
Intravitreal Ets1 siRNA alleviates choroidal neovascularization in a mouse model of age-related macular degeneration
In this study, Ets1 increased and localized in the macrophages and microglia of a mouse laser-induced CNV region. Ets1 siRNA intravitreal injection ameliorated the leakage and area of CNV, as well as inhibiting the dysfunction of retinal pigment epithelium (RPE) cells and the activation of macrophages/microglia. Taken together, we provide a new insight into the molecular mechanism of CNV progression, in which Ets1 can be a new therapeutic target.
Source: Cell and Tissue Research - February 28, 2019 Category: Cytology Source Type: research
IGF-1 regulates Ang II and VEGF signaling pathways in retinal neovascularization.
CONCLUSIONS: The occurrence of retinal neovascularization is related to the reduction of IGF-1 expression and the increase of Ang II and VEGF.
PMID: 30338783 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 21, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
In conclusion, ADMA contributes to the neovascularization of retina in diabetic mellitus, which is regulated by ephrinB2.
PMID: 29777874 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - May 16, 2018 Category: Drugs & Pharmacology Authors: Du MR, Yan L, Li NS, Wang YJ, Zhou T, Jiang JL Tags: Vascul Pharmacol Source Type: research
GSE113008 mRNA sequencing of Aniridia limbal epithelial cells.
Contributors : Karl Nordstr öm ; Jasmin KirchSeries Type : Expression profiling by high throughput sequencingOrganism :PAX6-related Aniridia is a sight-threatening disease due to progression of secondary glaucoma and aniridia associated keratopathy (AAK). Changes or loss of limbal epithelial progenitors causes the epithelial surfaces defects. We analyzed how PAX6 contribute to this with a two-step approach. 1) mRNA Sequencing of limbal epithelial cells isolated from controls and aniridia patients. 2) confirming the bioinformatical and literature-based result list on a siRNA based primary aniridia cell model (PAX6- knockdo...
Source: GEO: Gene Expression Omnibus - October 24, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
