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Total 327 results found since Jan 2013.

Role of moesin and its phosphorylation in VE-cadherin expression and distribution in endothelial adherens junctions
CONCLUSION: This study suggests that moesin regulates VE-cadherin expression through KLF4 and the state of moesin phosphorylation at Thr558 affects the integrity of VE-cadherin-based AJs. Thr558 phosphor-moesin mediates AGE-induced VE-cadherin internalization through cytoskeleton reassembling.PMID:36100057 | DOI:10.1016/j.cellsig.2022.110466
Source: Cellular Signalling - September 13, 2022 Category: Cytology Authors: Bingyu Li Xiaoxia Huang Jiayi Wei Hang Huang Zhuanhua Liu Jiaqing Hu Qin Zhang Yanjia Chen Yun Cui Zhenfeng Chen Xiaohua Guo Qiaobing Huang Source Type: research

Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations
Retinitis pigmentosa (RP) is the most common cause of hereditary blindness, and may occur in isolation as a non-syndromic condition or alongside other features in a syndromic presentation. Biallelic or monoallelic mutations in one of eight genes encoding pre-mRNA splicing factors are associated with non-syndromic RP. The molecular mechanism of disease remains incompletely understood, limiting opportunities for targeted treatment. Here we use CRISPR and base edited PRPF6 and PRPF31 mutant cell lines, and publicly-available data from human PRPF31+/− patient derived retinal organoids and PRPF31 siRNA-treated organotypic ret...
Source: Frontiers in Genetics - September 13, 2022 Category: Genetics & Stem Cells Source Type: research

TNFAIP3 is anti-inflammatory in the retinal vasculature
CONCLUSIONS: TNFAIP3 serves as an anti-inflammatory factor in the retinal vasculature. Epac1 regulates TNFAIP3. TNFAIP3 may offer a new mechanism for regulating inflammation and permeability in the retinal vasculature.PMID:36034737 | PMC:PMC9352365
Source: Molecular Vision - August 29, 2022 Category: Molecular Biology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research