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Total 327 results found since Jan 2013.

ARHGEF10L Promotes Cervical Tumorigenesis via RhoA-Mediated Signaling
This study investigated the pathogenic role and mechanism of ARHGEF10L in cervical tumors.METHODS: The HeLa cell line, which was derived from cervical carcinoma, was transfected with ARHGEF10L-overexpressing plasmids or anti-ARHGEF10L siRNA. Cell counting kit-8 assays, wound-healing assays, and cell apoptosis assays were performed to investigate the effects of ARHGEF10L on cell activities. A Rho pull-down assay and RNA-sequencing analysis were performed to investigate the pathogenic pathway of ARHGEF10L involvement in cervical tumors.RESULTS: ARHGEF10L overexpression promoted cell proliferation and migration, reduced cell ...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Junyi Tang Kehua Fang Chang Li Xiaotian Chang Source Type: research

Astaxanthin mediated regulation of VEGF through HIF1 α and XBP1 signaling pathway: An insight from ARPE-19 cell and streptozotocin mediated diabetic rat model
Exp Eye Res. 2021 Mar 28:108555. doi: 10.1016/j.exer.2021.108555. Online ahead of print.ABSTRACTBreakdown of outer blood-retina barrier (BRB) has been associated with the pathogenesis of diabetic retinopathy (DR) and diabetic macular edema (DME). Vascular endothelial growth factor (VEGF) might play a detrimental role in the pathogenesis of DME, a major clinical manifestation of DR. In the present study, we investigated the inhibitory mechanism of astaxanthin on VEGF and its upstream signaling pathways under in vitro and in vivo conditions. Astaxanthin has been observed to downregulate VEGF expression under hyperglycemic (H...
Source: Experimental Eye Research - March 31, 2021 Category: Opthalmology Authors: Rajasekar Janani Rani Elavarasan Anitha Madan Kumar Perumal Peethambaran Divya Vallikannan Baskaran Source Type: research

Antibody ‐Functionalized Gold Nanostar‐Mediated On‐Resonance Picosecond Laser Optoporation for Targeted Delivery of RNA Therapeutics
In this study, an elaborated plasmonic optoporation approach is proposed to efficiently and selectively transfect specific cells. The site ‐specific optoporation is obtained by tuning the spectral range of a supercontinuum pulsed picosecond laser in order for each individual cell binding gold nanostar with their unique resonance peak to magnify the local field strength in the near‐infrared region and facilitate a selective delivery of small interfering RNA, messenger RNA, and Cas9‐ribonucleoprotein into human retinal pigment epithelial cells. Numerical simulations indicate that optoporation is not due to a plasma‐m...
Source: Small - March 30, 2021 Category: Nanotechnology Authors: Morteza Hasanzadeh Kafshgari, Leonidas Agiotis, Isabelle Largilli ère, Sergiy Patskovsky, Michel Meunier Tags: Research Article Source Type: research

Erythropoietin inhibits apoptosis of retinal ganglion cells induced by high glucose through JNK signaling pathway
J Biol Regul Homeost Agents. 2021 Mar 23;35(2). doi: 10.23812/20-646-A. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect of erythropoietin (EPO) on the apoptosis of retinal ganglion cells (RGCs) induced by high glucose and its mechanism. Rat primary RGCs were extracted to establish high glucose-induced apoptosis models using a 30 mM high-glucose medium. Then flow cytometry, cell counting kit-8 (CCK-8) assay and Western blotting assay were performed to detect the effects of high-, medium- and low-dose EPO on the apoptosis of RGCs induced by high glucose. Next, the molecular mechanism by whic...
Source: Journal of Biological Regulators and Homeostatic Agents - March 23, 2021 Category: Biomedical Science Authors: Y X Qi X J Su L L Wei J Zhang Source Type: research

Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration
Biochem Biophys Res Commun. 2021 Mar 16;551:148-154. doi: 10.1016/j.bbrc.2021.02.148. Online ahead of print.ABSTRACTWaste product deposition and light stress in the retinal pigment epithelium (RPE) are crucial factors in the pathogenesis of various retinal degenerative diseases, including age-related macular degeneration (AMD), a leading cause of vision loss in elderly individuals worldwide. Given that autophagy in the RPE suppresses waste accumulation, determining the molecular mechanism by which autophagy is compromised in degeneration is necessary. Using polarized human RPE sheets, we found that bis-retinoid N-retinyl-N...
Source: Biochemical and Biophysical Research communications - March 19, 2021 Category: Biochemistry Authors: Satoru Ando Noriyasu Hashida Daisuke Yamashita Tsuyoshi Kawabata Kazunobu Asao Satoshi Kawasaki Kazushi Sakurai Tamotsu Yoshimori Kohji Nishida Source Type: research

Decreased expression of TIPE2 in the eye under high-glucose conditions tested in vivo and in vitro
CONCLUSIONS: TIPE2 down-expressed and exerted anti-VEGF and anti-inflammatory function in the high-glucose environment. TIPE2 was verified to be involved in the process of DR and might be a potential regulator for DR development.PMID:33725633 | DOI:10.1016/j.intimp.2021.107517
Source: International Immunopharmacology - March 16, 2021 Category: Allergy & Immunology Authors: Ling-Ge Suo Rui-Xi Qin Yan-Yan Cui Xue-Jiao Qin Source Type: research