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Total 327 results found since Jan 2013.

Investigation of the Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 in Diabetic Retinopathy
CONCLUSIONS: CEACAM1 might play a role in the pathology of PDR. CEACAM1 might be a therapeutic target for retinal neovasculariztion.PMID:37023410 | DOI:10.1080/09273948.2023.2192272
Source: Ocular Immunology and Inflammation - April 6, 2023 Category: Allergy & Immunology Authors: Yuanqi Wang Junhui Shen Jianghua Hu Houfa Yin Zhiqing Chen Xiaoyun Fang Li Zhang Source Type: research

Molecules, Vol. 28, Pages 2236: Lipopolysaccharide Activating NF-kB Signaling by Regulates HTRA1 Expression in Human Retinal Pigment Epithelial Cells
glin Yang Inflammation and elevated expression of high temperature requirement A serine peptidase 1 (HTRA1) are known high risk factors for age-related macular degeneration (AMD). However, the specific mechanism that HTRA1 causes AMD and the relationship between HTRA1 and inflammation remains unclear. We found that lipopolysaccharide (LPS) induced inflammation enhanced the expression of HTRA1, NF-κB, and p-p65 in ARPE-19 cells. Overexpression of HTRA1 up-regulated NF-κB expression, and on the other hand knockdown of HTRA1 down-regulated the expression of NF-κB. Moreover, NF-&am...
Source: Molecules - February 28, 2023 Category: Chemistry Authors: Shengliu Pan Min Liu Huijuan Xu Junlan Chuan Zhenglin Yang Tags: Article Source Type: research

Effective treatment of retinal neovascular leakage with fusogenic porous silicon nanoparticles delivering VEGF-siRNA
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - February 7, 2023 Category: Nanotechnology Authors: Joel F Grondek Kristyn Huffman Ella Jiyoon Lee Melina Cavichini Alexandra Warter Fritz Gerald P Kalaw Anna Heinke Ruhan Fan Lingyun Cheng Michael J Sailor William R Freeman Source Type: research

Inhibition of diabetes-induced Drp1 deSUMOylation prevents retinal vascular lesions associated with diabetic retinopathy
Exp Eye Res. 2022 Nov 23:109334. doi: 10.1016/j.exer.2022.109334. Online ahead of print.ABSTRACTRetinal microvascular endothelial cell (RMEC) injury plays an important role in the pathophysiology diabetic retinopathy (DR). The GTPase dynamin-related protein 1 (Drp1), crucial to mitochondrial dynamics, has been implicated in hyperglycaemia-induced microvascular damage. Moreover, Drp1 can be deSUMOylated by the enzyme sentrin/SUMO-specific protease 3 (SENP3). Whether SENP3/deSUMOylated Drp1 can aggravate DR is unclear. Therefore, we designed this experiment to investigate the role of SENP3/desumoylated Drp1 in DR in vitro an...
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Min Chen Qianhui Zhang Shun Wang Feng Zheng Source Type: research

Nestin contributes to laser choroidal and retinal neovascularization
CONCLUSIONS: Our results confirmed the presence of nestin in glial (e.g., astrocytes), reactive Müller, and endothelial cells. They demonstrated their critical involvement in a rat model of retinal and choroidal neovascularization experimentally induced using ocular laser impacts.PMID:36284669 | PMC:PMC9514549
Source: Molecular Vision - October 26, 2022 Category: Molecular Biology Authors: Sofiane Miloudi Maud Valensi Mohamed El Sanharawi Marc M Abitbol Francine Behar-Cohen Claudine Versaux-Botteri Source Type: research