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Nutrition: Turmeric

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Total 89 results found since Jan 2013.

Curcumin analogue 1, 5-Bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibit enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity.
Abstract Curcumin, a phytochemical agent in the spice turmeric, has received increasing attention for its anticancer, anti-inflammatory and antioxidant properties. However, application of curcumin have been limited due to its insolubility in water and poor bioavailability both clinically and experimentally. In addition, the protective effects and mechanisms of curcumin in eye diseases have been poorly studied. In the present study, we synthesized a curcumin analogue, 1, 5-Bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one (C3), which displayed improved protective effect against acrolein-induced toxicity in a human...
Source: Toxicology and Applied Pharmacology - August 13, 2013 Category: Toxicology Authors: Li Y, Zou X, Cao K, Xu J, Yue T, Dai F, Zhou B, Lu W, Feng Z, Liu J Tags: Toxicol Appl Pharmacol Source Type: research

Curcumin induces radiosensitivity of in vitro and in vivo cancer models by modulating pre-mRNA processing factor 4 (Prp4).
Abstract Radiation therapy plays a central role in adjuvant strategies for the treatment of both pre- and post-operative human cancers. However, radiation therapy has low efficacy against cancer cells displaying radio-resistant phenotypes. Ionizing radiation has been shown to enhance ROS generation, which mediates apoptotic cell death. Further, concomitant use of sensitizers with radiation improves the efficiency of radiotherapy against a variety of human cancers. Here, the radio-sensitizing effect of curcumin (a derivative of turmeric) was investigated against growth of HCT-15 cells and tumor induction in C57BL/6...
Source: Chemico-Biological Interactions - October 18, 2013 Category: Molecular Biology Authors: Shehzad A, Park JW, Lee J, Lee YS Tags: Chem Biol Interact Source Type: research

Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase
Abstract Fatty acid synthase (FAS) is highly expressed in many kinds of human cancers, including liver cancer. Curcumin is the major active ingredient of Curcuma longa and has long been used to treat a variety of maladies. In the present study, we investigated the potential use of curcumin as a kind of FAS inhibitor for chemoprevention of liver cancer. Curcumin induced HepG2 cell apoptosis with the IC50 value of 8.84 μg/ml. It inhibited intracellular FAS activity, and downregulated expression and mRNA level of FAS in a dose-dependent manner. In addition, sodium palmitate could rescue cell apoptosis induced by c...
Source: Targeted Oncology - September 1, 2014 Category: Cancer & Oncology Source Type: research

Abstract 2283: Potent curcumin analog FLLL-12 targets both intrinsic and extrinsic signaling pathways to induce apoptosis in lung cancers
Conclusions: Our results strongly suggest that FLLL-12 is a potent curcumin analog that induces apoptosis of lung cancer cell lines by targeting: (1) intrinsic pathways via transcriptional inhibition of EGFR and AKT and induction of BIM, and (2) extrinsic pathway via induction of DR5. Future in vivo studies using appropriate animal models are warranted for further development of this promising compound for cancer prevention and/or treatment for lung cancer. (Supported by R03CA171663, P50CA128613 and Robbins Scholar Award of Winship Cancer Institute of Emory University). Citation Format: A.R.M. Ruhul Amin, Abedul Haque, Moh...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Amin, A. R. M. R., Haque, A., Rahman, M. A., Fuchs, J. R., Chen, Z. G., Shin, D. M. Tags: Molecular and Cellular Biology Source Type: research

Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/ß-catenin negative feedback loop
Conclusions: Cumulatively, our findings disclose that curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative feedback loop.
Source: Stem Cell Research and Therapy - October 14, 2014 Category: Stem Cells Authors: Shravanti MukherjeeMinakshi MazumdarSamik ChakrabortyArgha MannaShilpi SahaPoulami KhanPushpak BhattacharjeeDeblina GuhaArghya AdhikarySanhita MukhjerjeeTanya Das Source Type: research

The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway
Conclusions: Our study established PI3K/Akt-SKP2-Cip/Kips signaling pathway is involved in the mechanism of action of curcumin and revealed that the discrepant modulation of this pathway by curcumin is responsible for the differential susceptibilities of these two cell types to curcumin.
Source: Cancer Cell International - November 30, 2014 Category: Cancer & Oncology Authors: Tao JiaLi ZhangYale DuanMin ZhangGang WangJun ZhangZheng Zhao Source Type: research

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.
This study aims to investigate the action of curcumin in the hippocampus subjected to glutamate neurotoxicity. Glutamate stimulation induced reactive oxygen species (ROS), endoplasmic reticulum stress (ER stress) and TXNIP/NLRP3 inflammasome activation, leading to the damage in the hippocampus. Curcumin treatment in the hippocampus or SH-SY5Y cells inhibited IRE1α and PERK phosphorylation with suppression of intracellular ROS production. Curcumin increased AMPK activity and knockdown of AMPKα with specific siRNA abrogated its inhibitory effects on IRE1α and PERK phosphorylation, indicating that AMPK activity was essenti...
Source: Toxicology and Applied Pharmacology - March 16, 2015 Category: Toxicology Authors: Li Y, Li J, Li S, Li Y, Wang X, Liu B, Fu Q, Ma S Tags: Toxicol Appl Pharmacol Source Type: research

Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung cancer cells.
Abstract Lung cancer is still in the first place in terms of both incidence and mortality. In the present study, we demonstrated the effect of curcumin, a phytochemical of the plant Curcuma longa, on expression and activation of Axl receptor tyrosine kinase (RTK) which plays an important role in cell survival, proliferation and anti-apoptosis. Curcumin treatment of non-small cell lung cancer (NSCLC) A549 and H460 cells, was found to decrease Axl protein as well as mRNA levels in a dose- and time-dependent manner. Axl promoter activity was also reduced by curcumin, indicating that curcumin downregulates Axl express...
Source: International Journal of Oncology - October 21, 2015 Category: Cancer & Oncology Authors: Kim KC, Baek SH, Lee C Tags: Int J Oncol Source Type: research

GADD45α modulates curcumin sensitivity through c-Abl- and JNK-dependent signaling pathways in a mismatch repair-dependent manner.
In this report, we show that the protein levels of gadd45α, whose transcript levels are increased during DNA damage and stress signals, are upregulated following curcumin treatment in a dose- and time-dependent manner. We further observed that cells compromised for Mlh1 function (HCT116 + Ch2) displayed ~twofold increased GADD45α upregulation compared to similarly treated proficient counterparts (HCT116 + Ch3). Similarly, suppression of Mlh1 using ShRNA increased GADD45α upregulation upon curcumin treatment. On the other hand, suppression of GADD45α using SiRNA-blocked curcumin-induced cell death induction in Mlh1-...
Source: Molecular and Cellular Biochemistry - January 30, 2016 Category: Biochemistry Authors: Naick H, Jin S, Baskaran R Tags: Mol Cell Biochem Source Type: research

Curcumin inhibits tumor epithelial‑mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells.
Authors: Zhang Z, Chen H, Xu C, Song L, Huang L, Lai Y, Wang Y, Chen H, Gu D, Ren L, Yao Q Abstract Tumor invasion and metastasis are closely associated with epithelial‑mesenchymal transition (EMT). EMT refers to epithelial cells under physiological and pathological conditions that are specific to mesenchymal transition. Curcumin inhibits EMT progression via Wnt signaling. The Wnt signaling pathway is a conservative EMT‑related signaling pathway that is involved in the development of various tumors. In the present study, MTS assays were employed to analyze the proliferation of curcumin‑treated cells. Naked c...
Source: Oncology Reports - March 19, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.
CONCLUSIONS: This study revealed the AKT/PTEN/FOXO4 pathway as a potential candidate of target for treatment of p53-null liver cancers. PMID: 28769986 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - August 6, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.
Abstract Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Involvement of ADP ribosylation factor (Arf) in agonist-induced activation of PLD is known for smooth muscle cells of systemic arteries, but not in pulmonary artery smooth muscle cells (PASMCs). Additionally, role of cytohesin in this scenario is unknown in PASMCs. We, therefore, determined the involvement of Arf and cytohesin in U46619-induced stimulation of PLD in PASMCs, an...
Source: Molecular and Cellular Biochemistry - August 5, 2017 Category: Biochemistry Authors: Chakraborti S, Sarkar J, Bhuyan R, Chakraborti T Tags: Mol Cell Biochem Source Type: research

Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells
In conclusion, curcumin could induce lipocyte phenotype of activated HSCs via activating Nrf2. Nrf2 could be a target molecule for antifibrotic strategy.
Source: Biomedicine and Pharmacotherapy - August 19, 2017 Category: Drugs & Pharmacology Source Type: research

Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.
In conclusion, curcumin could induce lipocyte phenotype of activated HSCs via activating Nrf2. Nrf2 could be a target molecule for antifibrotic strategy. PMID: 28826090 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 18, 2017 Category: Drugs & Pharmacology Authors: Lu C, Xu W, Zheng S Tags: Biomed Pharmacother Source Type: research

OPN b and c Isoforms Doubtless Veto Anti-angiogenesis Effects of Curcumin in Combination with Conventional AML Regiment
Authors: Mirzaei A, Ghaffari SH, Nikbakht M, Kamranzadeh Foumani H, Vaezi M, Mohammadi S, Alimoghaddam K, Ghavamzadeh A Abstract Osteopontin (OPN) is an extracellular structural protein that is secreted by osteoblasts and hematopoietic cells. It suppresses the proliferation of hematopoietic stem and also plays an important role in promoting survival and drug resistance in leukemic stem cells (LSCs). Since the role of OPN isoforms in AML angiogenesis are remaining controversial, in the present study, we aimed to evaluate whether curcumin (CUR), as a known natural component with anti-angiogenesis effects, in a combin...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2017 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research