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Total 89 results found since Jan 2013.

Curcumin exerts protective effects against hypoxia ‑reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease 1 in SH‑SY5Y cells: Involvement of the PI3K/AKT pathway.
Curcumin exerts protective effects against hypoxia‑reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease 1 in SH‑SY5Y cells: Involvement of the PI3K/AKT pathway. Int J Mol Med. 2020 Feb 04;: Authors: Wu L, Jiang C, Kang Y, Dai Y, Fang W, Huang P Abstract Curcumin, a polyphenolic compound extracted from the plant Curcuma longa, has been reported to exert neuroprotective effects against cerebral ischemia reperfusion (I/R) injury. However, the mechanisms underlying these effects remain to be fully elucidated. Emerging evidence indicated that apurinic/apyrimidinic endonuclea...
Source: International Journal of Molecular Medicine - February 3, 2020 Category: Molecular Biology Authors: Wu L, Jiang C, Kang Y, Dai Y, Fang W, Huang P Tags: Int J Mol Med Source Type: research

Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation.
This study provides insight into potential therapeutic approaches for TMJ OA. PMID: 32124251 [PubMed - as supplied by publisher]
Source: Cell Stress and Chaperones - March 1, 2020 Category: Cytology Authors: Jiang C, Luo P, Li X, Liu P, Li Y, Xu J Tags: Cell Stress Chaperones Source Type: research

Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF- κB Pathways by Electrophilic/Non-Electrophilic Compounds
The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 anti-inflammatory activity has been related to the crosstalk with the transcription factor NF-κB, a pivotal mediator of inflammatory responses and of multiple aspects of innate and adaptative immune functions. However, the underlying molecular basis has not been completely clarified. By combining into new chemical entities, the hydroxycinnamoyl motif from curcumin and the allyl mercaptan moiety of garlic organosulfur compounds, we tested a set...
Source: Frontiers in Pharmacology - August 13, 2020 Category: Drugs & Pharmacology Source Type: research

Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression.
Abstract Radiotherapy has been reported to cause cancer metastasis. Thus, a new strategy for radiotherapy must be developed to avoid this side effect. A549 cells were exposed to radiation to induce an epithelial-mesenchymal transition (EMT) cell model. Real-time PCR and western blotting were used to detect mRNA and protein expression levels, and Transwell invasion and wound healing assays were used to detect cell migration and invasion. ELISA was used to detect soluble E-cadherin (sE-cad) secretion. siRNA was used to silence MMP9 expression. The results show that A549R cells exhibited an EMT phenotype with increas...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Deng X, Chen C, Wu F, Qiu L, Ke Q, Sun R, Duan Q, Luo M, Luo Z Tags: Technol Cancer Res Treat Source Type: research

Molecules, Vol. 26, Pages 2382: Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies
arrabi Kwang Seok Ahn The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity against different cancers in both pre-clinical and clinical studies. However, drug resistance has restricted its potential in the treatment of cancer patients. CP can promote levels of free radicals, particularly reactive oxygen species (ROS) to induce cell death. Due to the double-edged sword role of ROS ...
Source: Molecules - April 19, 2021 Category: Chemistry Authors: Sepideh Mirzaei Kiavash Hushmandi Amirhossein Zabolian Hossein Saleki Seyed Mohammad Reza Torabi Adnan Ranjbar SeyedHesam SeyedSaleh Seyed Omid Sharifzadeh Haroon Khan Milad Ashrafizadeh Ali Zarrabi Kwang Seok Ahn Tags: Review Source Type: research

Curcumin Blunts IL-6 Dependent Endothelial ‐to‐Mesenchymal Transition to Alleviate Renal Allograft Fibrosis Through Autophagy Activation
Fibrosis contributes to graft loss in chronic renal allograft injury. Endothelial‐to‐mesenchymal transition (EndMT) plays an important role in the development of fibrosis following kidney transplantation. Autophagy plays an important role in the homeostasis of diverse cell types including endothelial cells. Here we demonstrate that inhibition of autophagy by treatment with 3-methyladenine (3-MA) or by silencing autophagy-related (ATG)5 promoted interleukin (IL)-6–dependent EndMT in human umbilical vein endothelial cells (HUVECs) and human renal glomerular endothelial cells (HRGECs), and autophagy inactivation was ass...
Source: Frontiers in Immunology - May 28, 2021 Category: Allergy & Immunology Source Type: research

Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway
CONCLUSIONS: These results implied that ERK, PEA3, and AP-1 participate in hypoxia-induced Pref-1 expression in human lung fibroblasts.PMID:34229599 | DOI:10.1186/s10020-021-00336-w
Source: Molecular Medicine - July 7, 2021 Category: Molecular Biology Authors: Wun-Hao Cheng Chia-Ling Chen Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research

The involvement of epithelial-to-mesenchymal transition in doxorubicin resistance: Possible molecular targets
Eur J Pharmacol. 2021 Jul 13:174344. doi: 10.1016/j.ejphar.2021.174344. Online ahead of print.ABSTRACTConsidering the fact that cancer cells can switch among various molecular pathways and mechanisms to ensure their progression, chemotherapy is no longer effective enough in cancer therapy. As an anti-tumor agent, doxorubicin (DOX) is derived from Streptomyces peucetius and can induce cytotoxicity by binding to topoisomerase enzymes to suppress DNA replication, leading to apoptosis and cell cycle arrest. However, efficacy of DOX in suppressing cancer progression is restricted by development of drug resistance. Cancer cells ...
Source: European Journal of Pharmacology - July 16, 2021 Category: Drugs & Pharmacology Authors: Sepideh Mirzaei Asal Jalal Abadi Mohammad Hossein Gholami Farid Hashemi Amirhossein Zabolian Kiavash Hushmandi Ali Zarrabi Maliheh Entezari Amir Reza Aref Haroon Khan Milad Ashrafizadeh Saeed Samarghandian Source Type: research

Ferritin: A Multifunctional Nanoplatform for Biological Detection, Imaging Diagnosis, and Drug Delivery
We reported that human HFn could selectively deliver a large amount of cargo into tumors in vivo via transferrin receptor 1 (TfR1)-mediated tumor-cell-specific targeting followed by rapid internalization. By the use of the intrinsic tumor-targeting property and unique nanocage structure of human HFn, a broad variety of cargo-loaded HFn formulations have been developed for biological analysis, imaging diagnosis, and medicine development. In view of the intrinsic tumor-targeting property, unique nanocage structure, lack of immunogenicity, and definite in vivo behavior, human HFn holds promise to promote therapeutic drugs, di...
Source: Cell Research - August 20, 2021 Category: Cytology Authors: Ningning Song Jianlin Zhang Jiao Zhai Juanji Hong Chang Yuan Minmin Liang Source Type: research

Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury
In this study, a hypoxia/reoxygenation (H/R)-induced renal tubular epithelial cell (TEC) injury model and an ischaemia/reperfusion (I/R)-induced mouse AKI model were treated with CUR with or without mitochondrial inhibitors (rotenone and FCCP) or siRNA targeting mitochondrial transcription factor A (TFAM). Changes in mitochondrial function, inflammation, the antioxidant system and related pathways were analysed. In vitro, CUR suppressed NFκB activation and cytokine production and induced NRF2/HO-1 signalling in TECs under H/R conditions. CUR treatment also reduced mitochondrial ROS (mtROS) and mitochondrial fragmentation ...
Source: J Cell Mol Med - September 17, 2021 Category: Molecular Biology Authors: Ling Li Shuyun Liu Yijie Zhou Meng Zhao Yizhuo Wang Chengshi Wang Peng Lou Rongshuang Huang Liang Ma Yanrong Lu Ping Fu Jingping Liu Source Type: research

Molecules, Vol. 27, Pages 1346: Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin
g-Han Lee Acute β-adrenergic stimulation contributes to heart failure. Here, we investigated the role of p53 in isoproterenol (ISO)-mediated metabolic and oxidative stress effects on cardiomyocytes and explored the direct protective effects offered by the antioxidant nutraceutical curcumin. Differentiated H9C2 rat cardiomyocytes treated with ISO were assayed for glucose uptake, lactate release, and mitochondrial reactive oxygen species (ROS) generation. Survival was assessed by sulforhodamine B assays. Cardiomyocytes showed significantly decreased glucose uptake and lactate release, as well as increased ce...
Source: Molecules - February 16, 2022 Category: Chemistry Authors: Jin Hee Lee Da Hae Kim MinA Kim Kyung-Ho Jung Kyung-Han Lee Tags: Article Source Type: research

Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
J Exp Clin Cancer Res. 2022 Jul 1;41(1):214. doi: 10.1186/s13046-022-02406-1.ABSTRACTBACKGROUND: One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic and epigenetic changes play significant roles in its development. The RNA molecules with more than 200 nucleotides in length are known as lncRNAs and these epigenetic factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional and epigenetic levels. LncRNAs play vital biological functions in cells and in pathological events, hence their expression u...
Source: Clinical Prostate Cancer - June 30, 2022 Category: Cancer & Oncology Authors: Sepideh Mirzaei Mahshid Deldar Abad Paskeh Elena Okina Mohammad Hossein Gholami Kiavash Hushmandi Mehrdad Hashemi Azuma Kalu Ali Zarrabi Noushin Nabavi Navid Rabiee Esmaeel Sharifi Hassan Karimi-Maleh Milad Ashrafizadeh Alan Prem Kumar Yuzhuo Wang Source Type: research