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Nutrition: High Fat

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Total 281 results found since Jan 2013.

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
In conclusion, these studies provide evidence that within the hypothalamic nuclei, leptin-glutamate signaling regulates the sympathetic activation. This may contribute to the sympathoexcitation commonly observed in obesity-related T2D. PMID: 28845307 [PubMed - in process]
Source: Neural Plasticity - August 30, 2017 Category: Neurology Authors: Zheng H, Liu X, Li Y, Patel KP Tags: Neural Plast Source Type: research

Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells.
CONCLUSIONS: Characteristic cellular damage resulted from released ROS following a high fat load to hepatoma cells. The damage was attenuated through early treatment with clofibrate, which may act as a hepatoprotectant by inducing FABP1 expression and in this manner, suppress intracellular ROS levels. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 28810950 [PubMed - in process]
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

LincRNA DYN ‐LRB2‐2 upregulates cholesterol efflux by decreasing TLR2 expression in macrophages
Conclusion: LincRNA DYN‐LRB2‐2 upregulates cholesterol efflux by decreasing TLR2 expression in macrophages. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 16, 2017 Category: Biochemistry Authors: Yongqiang Li, Shuxin Shen, Shoukun Ding, Lixia Wang Tags: Article Source Type: research

Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1 α deacetylation.
In this study we examined whether resveratrol alleviated cardiac dysfunction in diabetes by improving mitochondrial function via SIRT1-mediated PGC-1α deacetylation. T2DM was induced in rats by a high-fat diet combined with STZ injection. Diabetic rats were orally administered RSV (50 mg·kg(-1)·d(-1)) for 16 weeks. RSV administration significantly attenuated diabetes-induced cardiac dysfunction and hypertrophy evidenced by increasing ejection fraction (EF%), fraction shortening (FS%), ratio of early diastolic peak velocity (E velocity) and late diastolic peak velocity (A velocity) of the LV inflow (E/A ratio) and reduci...
Source: Acta Pharmacologica Sinica - August 3, 2017 Category: Drugs & Pharmacology Authors: Fang WJ, Wang CJ, He Y, Zhou YL, Peng XD, Liu SK Tags: Acta Pharmacol Sin Source Type: research

Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance.
Abstract Adipose dysfunction links tightly to hepatic insulin resistance and gluconeogenesis. Ilexgenin A is reported with the ability to regulate lipid profile and protect the liver against high fat diet (HFD) -induced impairment. Here, we propose that ilexgenin A ameliorates hepatic insulin signaling and gluconeogenesis by regulating lipolysis in white adipose tissue (WAT). Pyruvate tolerance test and biochemical analysis coupled with the ex vivo siRNA knockdown and co-culture studies demonstrate that ilexgenin A suppresses inflammation-associated lipolysis in epididymal fat pad via 5'-AMP-activated protein kina...
Source: European Journal of Pharmacology - July 21, 2017 Category: Drugs & Pharmacology Authors: Li LZ, Zhang T, Yang L, Zhang L, Wang L, Liu B, Liu K Tags: Eur J Pharmacol Source Type: research

Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice.
Abstract It has been demonstrated that dietary high fat diet negatively affects the pubertal mammary gland development. The aim of the present study was to investigate the effects of stearic acid (SA), an 18-carbon chain saturated fatty acid, on mammary gland development in pubertal mice and to explore the underlying mechanism. Our results demonstrated that dietary supplementation of 2% SA suppressed mammary duct development, with significant reduction of terminal end bud (TEB) number and ductal branch. In accord, the expression of proliferative marker Cyclin D1 was markedly decreased by dietary SA. Furthermore, d...
Source: Biochemical and Biophysical Research communications - July 13, 2017 Category: Biochemistry Authors: Meng Y, Yuan C, Zhang J, Zhang F, Fu Q, Zhu X, Shu G, Wang L, Gao P, Xi Q, Sun J, Zhang Y, Jiang Q, Wang S Tags: Biochem Biophys Res Commun Source Type: research

TNF- α Deficiency Prevents Renal Inflammation and Oxidative Stress in Obese Mice
Conclusion: These findings suggest that TNF- α plays an important role in the HFD induced kidney damage, and targeting TNF-α and/or its receptors could be a promising therapeutic regimen for progressive nephropathy.Kidney Blood Press Res 2017;42:416 –427
Source: Kidney and Blood Pressure Research - July 6, 2017 Category: Urology & Nephrology Source Type: research

Zinc deficiency exacerbates while zinc supplement attenuates cardiac hypertrophy in high-fat diet-induced obese mice through modulating p38 MAPK-dependent signaling.
Abstract Childhood obesity often leads to cardiovascular diseases, such as obesity-related cardiac hypertrophy (ORCH), in adulthood, due to chronic cardiac inflammation. Zinc is structurally and functionally essential for many transcription factors; however, its role in ORCH and underlying mechanism(s) remain unclear and were explored here in mice with obesity induced with high-fat diet (HFD). Four week old mice were fed on either HFD (60%kcal fat) or normal diet (ND, 10% kcal fat) for 3 or 6 months, respectively. Either diet contained one of three different zinc quantities: deficiency (ZD, 10mg zinc per 4057kcal)...
Source: Toxicology Letters - June 20, 2016 Category: Toxicology Authors: Wang S, Luo M, Zhang Z, Gu J, Chen J, Payne KM, Tan Y, Wang Y, Yin X, Zhang X, Liu GC, Wintergerst K, Liu Q, Zheng Y, Cai L Tags: Toxicol Lett Source Type: research

Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice.
Abstract Sphingosine 1-phosphate (S1P) is known to regulate insulin resistance in hepatocytes, skeletal muscle cells, and pancreatic β-cells. Among its five cognate receptors (S1pr1-5), S1P seems to counteract insulin signaling and confer insulin resistance via S1pr2 in these cells. S1P may also regulate insulin resistance in adipocytes, but the S1pr subtype(s) involved remains unknown. Here we investigated systemic glucose/insulin tolerance and phenotypes of epididymal adipocytes in high-fat diet-fed wild-type and S1pr2-deficient (S1pr2(-/-)) mice. Adult S1pr2(-/-) mice displayed smaller body/epididymal fat tiss...
Source: Endocrinology - March 4, 2016 Category: Endocrinology Authors: Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H Tags: Endocrinology Source Type: research

Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity.
Abstract Hepatic glucose production is promoted by forkhead box O1 (FoxO1) under conditions of insulin resistance. The overactivity of cannabinoid receptor type 1 (CB1R) partly causes increased liver fat deposits and metabolic dysfunction in obese rodents by decreasing mitochondrial function. The aim of the present study was to investigate the role of FoxO1 in CB1R-mediated insulin resistance through the dysregulation of mitochondrial function in the livers of mice with high-fat diet (HFD)-induced obesity. For this purpose, male C57BL/6 mice were randomly assigned to groups and either fed a standard diet (ST...
Source: International Journal of Molecular Medicine - January 29, 2016 Category: Molecular Biology Authors: Chen CC, Lee TY, Kwok CF, Hsu YP, Shih KC, Lin YJ, Ho LT Tags: Int J Mol Med Source Type: research

β‐Sitosterol attenuates high‐fat diet‐induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll‐like receptor 4 in the NF‐κB pathway
ConclusionThese findings indicate that β‐sitosterol ameliorates HFD‐induced colitis by inhibiting the binding of LPS to toll‐like receptor 4 in the NF‐κB pathway.
Source: Nahrung / Food - January 9, 2014 Category: Nutrition Authors: Kyung‐Ah Kim, In‐Ah Lee, Wan Gu, Supriya R. Hyam, Dong‐Hyun Kim Tags: Research Article Source Type: research