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Total 281 results found since Jan 2013.
Isoflavones from Semen Sojae Preparatum Improve Atherosclerosis and Oxidative Stress by Modulating Nrf2 Signaling Pathway through Estrogen-Like Effects
This study aimed to determine the effectiveness of Isoflavones from semen sojae preparatum (ISSP) in inhibiting oxidative stress and its important molecular mechanisms through in vivo and in vitro experiments. ApoE-/- mice were used to establish atherosclerosis models through a high-fat diet, and endothelial cells were used to establish oxidative stress injury models through ox-LDL induction. The degree of oxidative stress damage was assessed by detecting changes in ET-1, LDH, SOD, and MDA indicators. It was observed that after ISSP treatment, the oxidative stress damage of mice and endothelial cells was improved. The Nrf2...
Source: Evidence-based Complementary and Alternative Medicine - April 18, 2022 Category: Complementary Medicine Authors: Jinzhou Guo Jingxin Ma Kun Cai Haining Chen Ke Xie Binren Xu Desen Quan Jingyan Du Source Type: research
Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells
CONCLUSIONS: Together, our data indicate that Nrf2 insufficiency is linked to attenuation of atherosclerosis, and could diminish the pathological process by blunting LOX-1-mediated proliferation and migration of VSMCs.PMID:35299056 | DOI:10.1016/j.atherosclerosis.2022.02.025
Source: Atherosclerosis - March 17, 2022 Category: Cardiology Authors: Hongliang Li Wenwen Zhuang Tianqing Xiong Won Sun Park Song Zhang Yiwen Zha Jiali Yao Fangfang Wang Yongqi Yang Yingrui Chen Linqian Cai Ling Ling Duonan Yu Jingyan Liang Source Type: research
HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells
Cell Death Discov. 2022 Mar 12;8(1):112. doi: 10.1038/s41420-022-00906-9.ABSTRACTHistone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily, participates in various cardiovascular diseases. Recent evidence showed that pyroptosis was a form of inflammatory programmed cell death and is critical for atherosclerosis (AS). However, little is known about the effect of HDAC11 on endothelial cell pyroptosis in AS. Thus, this study aims to investigate the role of HDAC11 in vascular endothelial cell pyroptosis and its molecular mechanism. Firstly, we found that HDAC11 expression was up-regulated and pyroptosis occ...
Source: Atherosclerosis - March 13, 2022 Category: Cardiology Authors: Feng Yao Zhen Jin Zihan Zheng Xiaohan Lv Lingxuan Ren Jianjun Yang Danli Chen Bo Wang Wei Yang Lifang Chen Weirong Wang Jianli Gu Rong Lin Source Type: research
Laminaria japonica Polysaccharide Suppresses Atherosclerosis via Regulating Autophagy-Mediated Macrophage Polarization
J Agric Food Chem. 2022 Feb 15. doi: 10.1021/acs.jafc.1c07483. Online ahead of print.ABSTRACTThe present work aimed to explore the effect and underlying mechanism of a homogeneous Laminaria japonica polysaccharide (LJP61A) on macrophage polarization in high-fat-diet-fed LDLr-/- mice and Ox-LDL-induced macrophages. Results showed that LJP61A remarkably reduced the lesion burden in atherosclerotic mice, alleviated lipid deposition in Ox-LDL-stimulated macrophages, decreased the expression of M1 macrophage markers, and increased the expression of M2 macrophage markers, thus reducing the M1/M2 macrophage phenotype ratio. Meanw...
Source: Atherosclerosis - February 15, 2022 Category: Cardiology Authors: Xue-Ying Li Yu-Jing Wang Shun Chen Li-Hua Pan Qiang-Ming Li Jian-Ping Luo Xue-Qiang Zha Source Type: research
Targeting the KCa3.1 channel suppresses diabetes-associated atherosclerosis via the STAT3/CD36 axis
CONCLUSION: Blockade of macrophage KCa3.1 channel inhibit cellular oxidized low-density lipoprotein accumulation and decrease proinflammation factors expression via STAT3/CD36 axis. This study provided a novel therapeutic target to reduce the risk of atherosclerosis development in diabetic patients.PMID:35149165 | DOI:10.1016/j.diabres.2022.109776
Source: Atherosclerosis - February 12, 2022 Category: Cardiology Authors: Xiao-Xin Jiang Weikang Bian Yan-Rong Zhu Zhicheng Wang Peng Ye Yue Gu Hongsong Zhang Guangfeng Zuo Xiaobo Li Linlin Zhu Zhizhong Liu Chongxiu Sun Shao-Liang Chen Dai-Min Zhang Source Type: research
Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis
CONCLUSIONS: The testicular zinc transporter ZIP12 expression levels especially in spermatogonia and spermatozoa are higher than in other tissues. ZIP12 may play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis which help counteract declines in male fertility.PMID:35065654 | PMC:PMC8783530 | DOI:10.1186/s12958-022-00893-7
Source: Reproductive Biology - January 23, 2022 Category: Reproduction Medicine Authors: Xinye Zhu Chengxuan Yu Wangshu Wu Lei Shi Chenyi Jiang Li Wang Zhide Ding Yue Liu Source Type: research
Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine
Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. When FMO1 is silenced, the effects of high fat and TMA on TMAO are blocked. And the role of TMAO in NAFLD may be through the activation of UPR.PMID:35065293 | DOI:10.1016/j.bbrc.2022.01.060
Source: Biochemical and Biophysical Research communications - January 22, 2022 Category: Biochemistry Authors: Chunxia Shi Maohua Pei Yao Wang Qian Chen Pan Cao Luyi Zhang Jin Guo Wei Deng Luwen Wang Xun Li Zuojiong Gong Source Type: research
Ursodesoxycholic acid is an FFA4 agonist and reduces hepatic steatosis via FFA4 signaling
This study not only identified a new skeleton of FFA4 agonists, but also demonstrated that FFA4 signal was accounting for the protective effects of UDCA in the NAFLD treatment.PMID:35033554 | DOI:10.1016/j.ejphar.2022.174760
Source: European Journal of Pharmacology - January 16, 2022 Category: Drugs & Pharmacology Authors: Fangfang Xu Jun Wang Pan Wang Tao Hou Han Zhou Yaopeng Zhao Jixia Wang Yanfang Liu Xinmiao Liang Source Type: research
