Filtered By:
Source: Biochimica et Biophysica Acta
This page shows you your search results in order of date.
Order by Relevance | Date
Total 177 results found since Jan 2013.
Inhibition of PP2A ameliorates intervertebral disc degeneration by reducing annulus fibrosus cells apoptosis via p38/MAPK signal pathway
CONCLUSIONS: This study suggests that the downregulation of PP2 A could reduce AF cell apoptosis and degeneration via the p38/MAPK pathway. It also revealed that the inhibition of PP2 A is expected to be a therapeutic target for IVDD.PMID:37722489 | DOI:10.1016/j.bbadis.2023.166888
Source: Biochimica et Biophysica Acta - September 18, 2023 Category: Biochemistry Authors: Pengfei Zhu Xiexing Wu Li Ni Kai Chen Zhongchen Dong Jiacheng Du Fanchen Kong Yubo Mao Huaqiang Tao Miao Chu Haiqin Mao Huilin Yang Qinbai Liu Minfeng Gan Dechun Geng Source Type: research
Disruption of extracellular redox balance drives persistent lung fibrosis and impairs fibrosis resolution
Biochim Biophys Acta Mol Basis Dis. 2023 Aug 7:166842. doi: 10.1016/j.bbadis.2023.166842. Online ahead of print.ABSTRACTLung fibrosis is a devastating outcome of various diffuse parenchymal lung diseases. Despite rigorous research efforts, the mechanisms that propagate its progressive and nonresolving nature remain enigmatic. Oxidative stress has been implicated in the pathogenesis of lung fibrosis. However, the role of extracellular redox state in disease progression and resolution remains largely unexplored. Here, we show that compartmentalized control over extracellular reactive oxygen species (ROS) by aerosolized deliv...
Source: Biochimica et Biophysica Acta - August 9, 2023 Category: Biochemistry Authors: Ye Cui Zeran Yang Zhe Lv Jianfeng Lei Source Type: research
IGF2BP3-EGFR-AKT axis promotes breast cancer MDA-MB-231 cell growth
In this study, we identified the regulatory targets of IGF2BP3 in breast cancer MDA-MB-231 cells using RNA immunoprecipitation sequencing (RIP-seq) and high-throughput RNA-sequencing (RNA-seq). We discovered that these targets were enriched in the inflammatory response, endoplasmic reticulum stress, cell cycle, and cancer-related pathways, providing a new perspective for better understanding the functional mechanisms of IGF2BP3. Moreover, we identified that the epidermal growth factor receptor (EGFR), a downstream target, is regulated by IGF2BP3. IGF2BP3 binds to and protects EGFR mRNA from degradation and facilitates cell...
Source: Biochimica et Biophysica Acta - July 20, 2023 Category: Biochemistry Authors: Xintao Jing Cong Han Qian Li Fang Li Jinyuan Zhang Qiuyu Jiang Fei Zhao Chen Guo Jinfeng Chen Ting Jiang Xiaofei Wang Yanke Chen Chen Huang Source Type: research
G9a and DNMT1 inhibition modulates CDKN1A promoter methylation and the cell cycle leading to improvement in kidney fibrosis
CONCLUSIONS: Our data link G9a and DNMT1 to CDKN1A regulatory function and kidney fibrosis. Combined targeting G9a and DNMT1 could be a promising strategy for the treatment of kidney fibrosis.PMID:37356504 | DOI:10.1016/j.bbagen.2023.130417
Source: Biochimica et Biophysica Acta - June 25, 2023 Category: Biochemistry Authors: Yuanyuan Yang Zijian Zhou Lujia Wang Peng Gao Zhong Wu Source Type: research
Extracellular RNAs/TLR3 signaling contributes to acute intestinal injury induced by intestinal ischemia reperfusion in mice
In conclusion, exRNAs/TLR3 signaling is a key mechanism that regulates intestinal I/R injury in adult mice, and the TLR3/dsRNA complex inhibitor can be an effective approach for attenuating intestinal I/R-induced inflammatory response and apoptosis.PMID:37336369 | DOI:10.1016/j.bbadis.2023.166790
Source: Biochimica et Biophysica Acta - June 19, 2023 Category: Biochemistry Authors: Yu-Qiong Lei Yan-Tong Wan Guang-Tao Liang Yu-Hao Huang Peng Dong Si-Dan Luo Wen-Juan Zhang Wei-Feng Liu Ke-Xuan Liu Xi-Yang Zhang Source Type: research
Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells
Biochim Biophys Acta Mol Cell Res. 2023 Jun 12:119522. doi: 10.1016/j.bbamcr.2023.119522. Online ahead of print.ABSTRACTProstate cancer (PCa) continues to be one of the most common cancers in men worldwide. The six transmembrane epithelial antigen of the prostate 1 (STEAP1) protein is overexpressed in several types of human tumors, particularly in PCa. Our research group has demonstrated that STEAP1 overexpression is associated with PCa progression and aggressiveness. Therefore, understanding the cellular and molecular mechanisms triggered by STEAP1 overexpression will provide important insights to delineate new strategies...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Sandra M Rocha F átima M Santos S ílvia Socorro Lu ís A Passarinha Cl áudio J Maia Source Type: research
Epac1 participates in β < sub > 1 < /sub > -adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes
This study confirmed that Epac1 upregulation is indeed involved β1-AA-induced decreased cardiomyocyte autophagy through CE3F4 pretreatment, Epac1 siRNA transfection, western blot and immunofluorescence methods. On this basis, we constructed β1-AR and β2-AR knockout mice, and used receptor knockout mice, β1-AR selective blocker (atenolol), and the β2-AR/Gi-biased agonist ICI 118551 to show that β1-AA upregulated Epac1 expression through β1-AR and β2-AR to inhibit autophagy, and biased activation of β2-AR/Gi signaling downregulated myocardial Epac1 expression to reverse β1-AA-induced myocardial autophagy inhibition...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Yang Li Yuan Tian Shu Shi Xiaohong Hou Haihu Hao Mingxia Ma Na Ning Yuan Yuan Xiaohui Wang Huirong Liu Li Wang Source Type: research
Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells
Biochim Biophys Acta Mol Cell Res. 2023 Jun 12:119522. doi: 10.1016/j.bbamcr.2023.119522. Online ahead of print.ABSTRACTProstate cancer (PCa) continues to be one of the most common cancers in men worldwide. The six transmembrane epithelial antigen of the prostate 1 (STEAP1) protein is overexpressed in several types of human tumors, particularly in PCa. Our research group has demonstrated that STEAP1 overexpression is associated with PCa progression and aggressiveness. Therefore, understanding the cellular and molecular mechanisms triggered by STEAP1 overexpression will provide important insights to delineate new strategies...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Sandra M Rocha F átima M Santos S ílvia Socorro Lu ís A Passarinha Cl áudio J Maia Source Type: research
Epac1 participates in β < sub > 1 < /sub > -adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes
This study confirmed that Epac1 upregulation is indeed involved β1-AA-induced decreased cardiomyocyte autophagy through CE3F4 pretreatment, Epac1 siRNA transfection, western blot and immunofluorescence methods. On this basis, we constructed β1-AR and β2-AR knockout mice, and used receptor knockout mice, β1-AR selective blocker (atenolol), and the β2-AR/Gi-biased agonist ICI 118551 to show that β1-AA upregulated Epac1 expression through β1-AR and β2-AR to inhibit autophagy, and biased activation of β2-AR/Gi signaling downregulated myocardial Epac1 expression to reverse β1-AA-induced myocardial autophagy inhibition...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Yang Li Yuan Tian Shu Shi Xiaohong Hou Haihu Hao Mingxia Ma Na Ning Yuan Yuan Xiaohui Wang Huirong Liu Li Wang Source Type: research
Superparamagnetic iron oxide nanoparticles target BxPC-3 cells and silence MUC4 for theranostics of pancreatic cancer
CONCLUSION: PEI-SPION-siRNA may be beneficial as a novel theranostic tool for PC.PMID:37236323 | DOI:10.1016/j.bbagen.2023.130383
Source: Biochimica et Biophysica Acta - May 26, 2023 Category: Biochemistry Authors: Yu Pu Helin Ke Changqiang Wu Shaodan Xu Yang Xiao Lina Han Guorong Lyv Shilin Li Source Type: research
Single-cell RNA seq identifies Plg-R < sub > KT < /sub > -PLG as signals inducing phenotypic transformation of scar-associated macrophage in liver fibrosis
In this study, we aimed to characterize SAMs and elucidate the underlying mechanism of SAM transformation. Bile duct ligation (BDL) and carbon tetrachloride (CCl4) were used to induce mouse liver fibrosis. Non-parenchymal cells were isolated from normal/fibrotic livers and were analyzed using single cell RNA sequencing (scRNA-seq) or mass cytometry (CyTOF). The glucan-encapsulated siRNA particles (siRNA-GeRPs) was employed to perform macrophage selective gene knockdown. The results of scRNA-seq and CyTOF revealed that SAMs, which derived from bone marrow-derived macrophages (BMMs), accumulated in mouse fibrotic livers. Fur...
Source: Biochimica et Biophysica Acta - May 19, 2023 Category: Biochemistry Authors: Yuanru Yang Weiyang Li Chang Liu Jing Liu Lin Yang Wenhui Yue Le Yang Renmin Xue Kai Zhang Hang Zhang Na Chang Liying Li Source Type: research
