Filtered By:
Source: Biochimica et Biophysica Acta

This page shows you your search results in order of date. This is page number 8.

Order by Relevance | Date

Total 177 results found since Jan 2013.

Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).
Abstract Protective effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on non-alcoholic fatty liver disease has been demonstrated. FFA4 (also known as GPR120; a G protein-coupled receptor) has been suggested to be a target of n-3 PUFA. FFA4 expression in hepatocytes has also been reported from liver biopsies in child fatty liver patients. In order to assess the functional role of FFA4 in hepatic steatosis, we used an in vitro model of liver X receptor (LXR)-mediated hepatocellular steatosis. FFA4 expression was confirmed in Hep3B and HepG2 human hepatoma cells. T0901317 (a specific LXR activator) induced lip...
Source: Biochimica et Biophysica Acta - November 7, 2017 Category: Biochemistry Authors: Kang S, Huang J, Lee BK, Jung YS, Im E, Koh JM, Im DS Tags: Biochim Biophys Acta Source Type: research

β-cyclodextrin induces the differentiation of resident cardiac stem cells to cardiomyocytes through autophagy.
Abstract Cardiac stem cells (CSCs) have emerged as promising cell candidates to regenerate damaged hearts, because of the potential in differentiating to cardiomyocytes. However, the differentiation is difficult to trigger without inducers. Here we reported that β-cyclodextrin (β-CD) increased the expression of cardiac transcription factors (Nkx2.5 and GATA4), structural proteins (cardiac Troponin T, cTnt), transcriptional enhancer (Mef2c) and induced GATA4 nucleus translocation in adult resident CSCs, thus β-CD could be used to enhance myogenic transition. As the differentiation process was accompanied by auto...
Source: Biochimica et Biophysica Acta - May 15, 2017 Category: Biochemistry Authors: Shi X, Li W, Liu H, Yin D, Zhao J Tags: Biochim Biophys Acta Source Type: research

Activation of STAT3/HIF-1 α/Hes-1 axis promotes Trastuzumab resistance in HER2- overexpressing Breast cancer cells via down-regulation of PTEN.
CONCLUSION: The impairment of STAT3-HIF-1α-HES-1 pathway restored trastuzumab sensitivity through up-regulation of PTEN protein. GENERAL SIGNIFICANCE: These findings highlighted the signal integrator role of HIF-1α in STAT3-mediated trastuzumab resistance induction which would be valuable in designing more efficient chemosensitization strategies. PMID: 28499822 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - May 9, 2017 Category: Biochemistry Authors: Aghazadeh S, Yazdanparast R Tags: Biochim Biophys Acta Source Type: research

Dehydroepiandrosterone sulfate augments Blood-Brain Barrier and Tight Junction Protein Expression in Brain Endothelial Cells.
Abstract Tight junctions (TJ) between brain endothelial cells are essential for formation and maintenance of the blood-brain barrier (BBB). Although loss of BBB integrity is associated with several neuropathological disorders, treatments that augment or stabilise the BBB are scarce. Here we show that physiological concentrations of dehydroepiandrosterone sulfate (DHEAS) stimulate the expression of the TJ proteins zonula occludens-1 (ZO-1) and claudin-3 in the brain-derived endothelial cell line bEnd.3 and promote TJ formation between neighbouring cells, demonstrated by augmented transendothelial resistance across ...
Source: Biochimica et Biophysica Acta - May 8, 2017 Category: Biochemistry Authors: Papadopoulos D, Scheiner-Bobis G Tags: Biochim Biophys Acta Source Type: research

Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy.
Abstract In diabetes, matrix metalloproteinase-9 (MMP-9) is activated, which damages mitochondria, resulting in accelerated capillary cell apoptosis. Regulation of MMP-9 is controlled by multiple transcription factors including nuclear factor-kB (NF-kB) and activator protein-1 (AP-1). Binding of these transcription factors, however, can be regulated by poly(ADP-ribose) polymerase-1 (PARP-1), which forms a strong initiation complex at the promoter region and facilitates multiple rounds of gene transcription. This complex formation with the transcription factors is regulated by posttranslational acetylation of PARP-...
Source: Biochimica et Biophysica Acta - May 3, 2017 Category: Biochemistry Authors: Mishra M, Kowluru RA Tags: Biochim Biophys Acta Source Type: research

Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.
Abstract Endoplasmic reticulum (ER) stress is characterized by an accumulation of misfolded proteins, and ER stress reduction is essential for maintaining tissue homeostasis. However, the molecular mechanisms that protect cells from ER stress are not completely understood. The present study investigated the role of sestrin 2 (SESN2) on ER stress and sought to elucidate the mechanism responsible for the hepatoprotective effect of SESN2 in vitro and in vivo. Treatment with tunicamycin (Tm) increased SESN2 protein and mRNA levels and reporter gene activity. Activating transcription factor 6 (ATF6) bound to unfolded p...
Source: Biochimica et Biophysica Acta - April 19, 2017 Category: Biochemistry Authors: Jegal KH, Park SM, Cho SS, Byun SH, Ku SK, Kim SC, Ki SH, Cho IJ Tags: Biochim Biophys Acta Source Type: research

Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways.
CONCLUSION: The loss of DUSP3 activity markedly increases gamma radiation-induced DNA strand breaks, suggesting a potential novel role for DUSP3 in DNA repair. GENERAL SIGNIFICANCE: The radioresistance of tumor cells is effectively reduced by a combination of approaches through the inhibition of DUSPs. PMID: 28389334 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - April 4, 2017 Category: Biochemistry Authors: Torres TE, Russo LC, Santos A, Marques GR, Magalhaes YT, Tabassum S, Forti FL Tags: Biochim Biophys Acta Source Type: research

Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: relevance to Alzheimer's disease.
In conclusion, pharmacologically inhibiting (with low or high IU1 concentrations) or genetically down-regulating USP14 fail to enhance proteasomal degradation of Ub-proteins or Tau in neurons. PMID: 28372990 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 31, 2017 Category: Biochemistry Authors: Kiprowska MJ, Stepanova A, Todaro DR, Galkin A, Haas A, Wilson SM, Figueiredo-Pereira ME Tags: Biochim Biophys Acta Source Type: research

Identity and function of a cardiac mitochondrial small conductance Ca(2+)-activated K(+) channel splice variant.
Abstract We provide evidence for location and function of a small conductance, Ca(2+)-activated K(+) (SKCa) channel isoform 3 (SK3) in mitochondria (m) of guinea pig, rat and human ventricular myocytes. SKCa agonists protected isolated hearts and mitochondria against ischemia/reperfusion (IR) injury; SKCa antagonists worsened IR injury. Intravenous infusion of a SKCa channel agonist/antagonist, respectively, in intact rats was effective in reducing/enhancing regional infarct size induced by coronary artery occlusion. Localization of SK3 in mitochondria was evidenced by Western blot of inner mitochondrial membrane,...
Source: Biochimica et Biophysica Acta - March 22, 2017 Category: Biochemistry Authors: Yang M, Camara AK, Aldakkak M, Kwok WM, Stowe DF Tags: Biochim Biophys Acta Source Type: research

Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.
In conclusion, we have uncovered a novel molecular signaling pathway for the pathogenesis of CAD, which involves a novel gene-gene regulatory network. We show that ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis. PMID: 28341552 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 21, 2017 Category: Biochemistry Authors: Luo C, Wang F, Ren X, Ke T, Xu C, Tang B, Qin S, Yao Y, Chen Q, Wang QK Tags: Biochim Biophys Acta Source Type: research

Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier.
Abstract Impaired cholesterol/lipoprotein metabolism is linked to neurodegenerative diseases such as Alzheimer's disease (AD). Cerebral cholesterol homeostasis is maintained by the highly efficient blood-brain barrier (BBB) and flux of the oxysterols 24(S)-hydroxycholesterol and 27-hydroxycholesterol, potent liver-X-receptor (LXR) activators. HDL and their apolipoproteins are crucial for cerebral lipid transfer, and loss of ATP binding cassette transporters (ABC)G1 and G4 results in toxic accumulation of oxysterols in the brain. The HDL-associated apolipoprotein (apo)M is positively correlated with pre-β HDL form...
Source: Biochimica et Biophysica Acta - March 13, 2017 Category: Biochemistry Authors: Kober AC, Manavalan AP, Tam-Amersdorfer C, Holmér A, Saeed A, Danesh EF, Zandl M, Albrecher NM, Björkhem I, Kostner GM, Dahlbäck B, Panzenboeck U Tags: Biochim Biophys Acta Source Type: research

Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1.
CONCLUSIONS: Our data demonstrate that AST improves cardiac function and attenuates fibrosis by decreasing phosphorylation and deacetylation of R-SMADs. SIRT1 contributes to AST's protective function by reducing acetylation of R-SMADs. GENERAL SIGNIFICANCE: These data suggest that AST may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis. PMID: 28300638 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 10, 2017 Category: Biochemistry Authors: Zhang J, Wang QZ, Zhao SH, Ji X, Qiu J, Wang J, Zhou Y, Cai Q, Zhang J, Gao HQ Tags: Biochim Biophys Acta Source Type: research

Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGI α signaling pathways.
Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGIα signaling pathways. Biochim Biophys Acta. 2017 Mar 02;: Authors: Rogacka D, Audzeyenka I, Rachubik P, Rychłowski M, Kasztan M, Jankowski M, Angielski S, Piwkowska A Abstract Podocytes are dynamic polarized cells on the surface of glomerular capillaries and an essential component of the glomerular filtration barrier. Insulin increases the activation of protein kinase G type Iα (PKGIα) subunits, leading to podocyte dysfunction. In addition, accumulating evidence suggests that TRPC6 channels are crucial mediator...
Source: Biochimica et Biophysica Acta - March 1, 2017 Category: Biochemistry Authors: Rogacka D, Audzeyenka I, Rachubik P, Rychłowski M, Kasztan M, Jankowski M, Angielski S, Piwkowska A Tags: Biochim Biophys Acta Source Type: research

Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression.
In conclusion, glucose-derived AGEs promote the invasion and metastasis of CRC partially through the RAGE/ERK/SP1/MMP2 cascade. These findings may provide an explanation for the poor prognoses of colorectal cancer in diabetic patients. PMID: 28237576 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - February 21, 2017 Category: Biochemistry Authors: Deng R, Wu H, Ran H, Kong X, Hu L, Wang X, Su Q Tags: Biochim Biophys Acta Source Type: research

Knockdown of sestrin2 increases pro-inflammatory reactions and ER stress in the endothelium via an AMPK dependent mechanism.
CONCLUSION: Knockdown of sesn2 aggravates atherosclerotic processes by increasing pro-inflammatory reactions and ER stress in the endothelium via an AMPK-dependent mechanism, suggesting that sesn2 might be a novel therapeutic target for atherosclerosis. PMID: 28215577 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - February 15, 2017 Category: Biochemistry Authors: Hwang HJ, Jung TW, Choi JH, Lee HJ, Chung HS, Seo JA, Kim SG, Kim NH, Choi KM, Choi DS, Baik SH, Yoo HJ Tags: Biochim Biophys Acta Source Type: research