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Source: Biochimica et Biophysica Acta
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Total 177 results found since Jan 2013.
Enhancing Acsl4 in absence of mTORC2/Rictor drove β-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production
Biochim Biophys Acta Mol Basis Dis. 2021 Aug 26:166261. doi: 10.1016/j.bbadis.2021.166261. Online ahead of print.ABSTRACTRapamycin insensitive companion of mechanistic target of Rapamycin (Rictor), the key component of mTOR complex 2 (mTORC2), controls both β-cell proliferation and function. We sought to study whether long chain acyl-CoA synthetase 4 (Acsl4) worked downstream of Rictor/mTORC2 to maintain β-cell functional mass. We found Acsl4 was positively regulated by Rictor at transcriptional and posttranslational levels in mouse β-cell. Infecting adenovirus expressing Acsl4 in β-cell-specific-Rictor-knockout (βRic...
Source: Biochimica et Biophysica Acta - August 29, 2021 Category: Biochemistry Authors: Canqi Cui Tingting Li Yun Xie Jie Yang Chenyang Fu Yixuan Qiu Linyan Shen Qicheng Ni Qidi Wang Aifang Nie Guang Ning Weiqing Wang Yanyun Gu Source Type: research
Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes
In conclusion, Grp75 or Mfn2 silencing and overexpression in Huh7 cells contribute to altering MAM integrity and cholesterol storage in opposite directions, but all promote triglyceride accumulation through distinct cellular pathways. This study also highlights that besides Mfn2, Grp75 could play a central role in hepatic lipid and cholesterol metabolism in obesity and NAFLD.PMID:34419589 | DOI:10.1016/j.bbalip.2021.159030
Source: Biochimica et Biophysica Acta - August 22, 2021 Category: Biochemistry Authors: Arthur Bassot Carina Prip Buus Ana ïs Alves Olivier Berdeaux Johan Perrier V éronique Lenoir Jingwei Ji-Cao Marie-Agn ès Berger Emmanuelle Loizon Stephanie Cabaret Baptiste Panthu Jennifer Rieusset B éatrice Morio Source Type: research
Deficiency of Heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21 < sup > cip1 < /sup > expression
Biochim Biophys Acta Mol Basis Dis. 2021 Jul 30:166233. doi: 10.1016/j.bbadis.2021.166233. Online ahead of print.ABSTRACTGenetic mutations in heat shock factor 4 (Hsf4) is associated with both congenital and age-related cataracts. Hsf4 regulates lens development through its ability to both activate and inhibit transcription. Previous studies suggested Hsf4 is involved in modulating cellular senescence depending on p21cip1 and p27 kip1 expression in MEF cells. Here, we found that Hsf4 acts as a suppressor of p21cip1 expression and plays an anti-senescence role during lens development. Knocking out Hsf4 facilitated UVB-induc...
Source: Biochimica et Biophysica Acta - August 2, 2021 Category: Biochemistry Authors: Xiukun Cui Chunxiao Du Simin Wan Dandan Wu Longjun Yan Jing Zhang Jing Li Hui Li Zhengyan Yang Hailong Zhang Jun Zhang Hongmei Mu Fengyan Zhang Xuyan Peng Mugen Liu Yanzhong Hu Source Type: research
Induction of microRNA hsa-let-7d-5p, and repression of HMGA2, contribute protection against lipid accumulation in macrophage 'foam' cells
This study established that exposure to lipoproteins, including acetylated LDL, induced macrophage expression of microRNA hsa-let-7d-5p, a sequence previously linked with tumour suppression, and repressed expression of one of its target genes, high mobility group AT hook 2 (HMGA2). A let-7d-5p mimic repressed expression of HMGA2 (18%; p<0.05) while a marked increase (2.9-fold; p<0.05) in expression of HMGA2 was noted in the presence of let-7d-5p inhibitor. Under these conditions, let-7d-5p mimic significantly (p<0.05) decreased total [10%], free [8%] and cholesteryl ester [21%] mass, while the inhibitor significan...
Source: Biochimica et Biophysica Acta - July 18, 2021 Category: Biochemistry Authors: Richard J Lightbody Janice M W Taylor Yvonne Dempsie Annette Graham Source Type: research
Caspase-3 and gasdermin E detection in peri-implantitis
In conclusion, our findings revealed a high expression of caspase-3 and GSDME in the inflamed biopsies of peri-implantitis and confirmed that the caspase-3/GSDME pathway mediates TNF-α-triggered pyroptosis in human gingival epithelium cells, which provides a new target for peri-implantitis treatment.PMID:34273529 | DOI:10.1016/j.bbadis.2021.166217
Source: Biochimica et Biophysica Acta - July 17, 2021 Category: Biochemistry Authors: Chaozhen Chen Zhiwei Jiang Qifeng Jiang Wei Dai Qin Shao Qianming Chen Ying Wang Guoli Yang Source Type: research
RAGE and αVβ3-integrin are essential for suPAR signaling in podocytes
This study has examined the initial transduction steps used by suPAR in cultured mouse podocytes. We now report that the receptor for advanced glycation end-products (RAGE) co-immunoprecipitates with αV and β3 integrin subunits, which have previously shown to initiate suPAR signal transduction at the podocyte cell surface. siRNA knock-down of RAGE attenuated Src phosphorylation evoked by either suPAR or by glycated albumin (AGE-BSA), a prototypical RAGE agonist. suPAR effects on Src phosphorylation were also blocked by the structurally dissimilar RAGE antagonists FPS-ZM1 and azeliragon, as well as by cilengitide, an inhi...
Source: Biochimica et Biophysica Acta - June 24, 2021 Category: Biochemistry Authors: Eun Young Kim Stuart E Dryer Source Type: research
TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts
This study assessed the effect of calcitriol on PRMT1-dependent fibroblast remodeling in human lung fibroblasts, and allergen-induced asthma in E3-rats. Fibroblasts were activated with thymic stromal lymphopoietin (TLSP); asthma was induced by ovalbumin inhalation in rats. The airway structure was assessed by immunohistology. Protein expression in fibroblasts and activation of the mitogen activated protein kinases were detected by Western-blotting. Transcription factor activation was determined by luciferase reporter assay. PRMT1 action was blocked by siRNA and PRMT-inhibition. Ovalbumin upregulated the expression of TSLP,...
Source: Biochimica et Biophysica Acta - June 20, 2021 Category: Biochemistry Authors: Ai Jin Xuemei Tang Weiqi Zhai Yuwen Li Qingzhu Sun Li Liu Xiaojun Yang Hui Ren Shemin Lu Source Type: research
Short interfering RNA delivered by a hybrid nanoparticl ße targeting VEGF: Biodistribution and anti-tumor effect
CONCLUSION: The hybrid system prepared was successful in promoting the RNAi effect in vivo with very low toxicity.GENERAL SIGNIFICANCE: This study shows the valuable development of a hybrid nanoparticle carrying VEGF siRNA, as well as their tumor targeting, accumulation and reduction in mice triple-negative breast cancer.PMID:34062235 | DOI:10.1016/j.bbagen.2021.129938
Source: Biochimica et Biophysica Acta - June 1, 2021 Category: Biochemistry Authors: Gabriela Regina Rosa Souza Milene Dalmina Jelver Alexander Sierra Restrepo Le ônidas João de Mello Junior Adny Henrique Silva Ana Gualberto Jacy Gameiro Dalton Dittz Andr é Avelino Pasa Frederico Pittella T ânia Beatriz Creczynski-Pasa Source Type: research
