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Source: Biochimica et Biophysica Acta

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Total 177 results found since Jan 2013.

Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 May 22:158972. doi: 10.1016/j.bbalip.2021.158972. Online ahead of print.ABSTRACTBioactive N-acylethanolamines (NAEs) include palmitoylethanolamide, oleoylethanolamide, and anandamide, which exert anti-inflammatory, anorexic, and cannabimimetic actions, respectively. The degradation of NAEs has been attributed to two hydrolases, fatty acid amide hydrolase and NAE acid amidase (NAAA). Acid ceramidase (AC) is a lysosomal enzyme that hydrolyzes ceramide (N-acylsphingosine), which resembles NAAA in structure and function. In the present study, we examined the role of AC in the deg...
Source: Biochimica et Biophysica Acta - May 25, 2021 Category: Biochemistry Authors: Kazuhito Tsuboi Tatsuya Tai Ryouhei Yamashita Hanif Ali Takashi Watanabe Toru Uyama Yoko Okamoto Keisuke Kitakaze Yasuhiro Takenouchi Shinji Go Iffat Ara Sonia Rahman Hitoshi Houchi Tamotsu Tanaka Yasuo Okamoto Akira Tokumura Junko Matsuda Natsuo Ueda Source Type: research

Acidic pH-induced changes in lipid nanoparticle membrane packing
Biochim Biophys Acta Biomembr. 2021 Apr 23:183627. doi: 10.1016/j.bbamem.2021.183627. Online ahead of print.ABSTRACTTo enable the release of the encapsulated nucleic acids into the cytosol of targeted cells, the interaction of lipid nanoparticles (LNPs) with endosomes is critical. We investigated changes in the physicochemical properties of LNPs containing ionizable cationic lipids that were induced by acidic pH, which reflects the conditions in the maturation of endosomes. We prepared a LNP containing an ionizable cationic lipid. The laurdan generalized polarization values, which are related to the hydration degree of the...
Source: Biochimica et Biophysica Acta - April 26, 2021 Category: Biochemistry Authors: Kyoka Koitabashi Hiroki Nagumo Mizuka Nakao Tomoko Machida Kohki Yoshida Kumiko Sakai-Kato Source Type: research

siRNA enrichment in Argonaute 2-depleted Blattella germanica
Conclusions/General significance The siRNAs produced from a dsRNA mapped heterogeneously along the length of the dsRNA and this arrangement depends on the dsRNA sequence. AGO2 exerts its role as nuclease on the siRNA duplexes independently of its action on the corresponding mRNA. This study sheds light on an extremely useful process for reverse genetics in laboratories, in addition to the design of more effective, specific, and eco-friendly pest-control strategies.PMID:33895310 | DOI:10.1016/j.bbagrm.2021.194704
Source: Biochimica et Biophysica Acta - April 25, 2021 Category: Biochemistry Authors: Jos é Carlos Montañés Carlos Rojano Guillem Ylla Maria Dolors Piulachs Jos é Luis Maestro Source Type: research

Expression of the tumor-expressed protein MageB2 enhances rRNA transcription
Biochim Biophys Acta Mol Cell Res. 2021 Mar 16:119015. doi: 10.1016/j.bbamcr.2021.119015. Online ahead of print.ABSTRACTAn essential requirement for cells to sustain a high proliferating rate is to be paired with enhanced protein synthesis through the production of ribosomes. For this reason, part of the growth-factor signaling pathways, are devoted to activate ribosome biogenesis. Enhanced production of ribosomes is a hallmark in cancer cells, which is boosted by different mechanisms. Here we report that the nucleolar tumor-protein MageB2, whose expression is associated with cell proliferation, also participates in riboso...
Source: Biochimica et Biophysica Acta - March 20, 2021 Category: Biochemistry Authors: Mar ía Fátima Ladelfa Leticia Yamila Peche Gast ón Ezequiel Amato Micaela Carolina Escalada Stefania Zampieri Franco Andr és Pascucci Andres Fernandez Benevento Dario Fernandez Do Porto Andrea Dardis Claudio Schneider Martin Monte Source Type: research

Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis.
Abstract Psoriatic plaques tend to localize to the knees and elbows, areas that are particularly subject to mechanical stress resulting from bending and friction. Moreover, plaques often develop at sites of mechanical trauma or injury (Koebner phenomenon). Nevertheless, mechanotransduction has never been linked to psoriasis. Polycystins (polycystin-1, PC1; polycystin-2, PC2) are mechanosensitive molecules that function as key regulators of cellular mechanosensitivity and mechanotransduction. The aim of this in vitro study was to investigate the role of polycystins in the development of psoriasis. We showed that PC...
Source: Biochimica et Biophysica Acta - August 2, 2018 Category: Biochemistry Authors: Gargalionis AN, Malakou LS, Adamopoulos C, Piperi C, Theochari I, Nokhbehsaim M, Deschner J, Kokkalis G, Korkolopoulou P, Papadavid E, Papavassiliou AG, Basdra EK Tags: Biochim Biophys Acta Source Type: research

Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells.
In conclusion, our data illustrate a novel epigenetic pathway that links PERP transcription to ROS-induced apoptosis in skeletal muscle cells. PMID: 30056131 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - July 26, 2018 Category: Biochemistry Authors: Li Z, Chen B, Dong W, Xu W, Song M, Fang M, Guo J, Xu Y Tags: Biochim Biophys Acta Source Type: research

The prostaglandin EP4 receptor is a master regulator of the expression of PGE2 receptors following inflammatory activation in human monocytic cells.
Abstract Prostaglandin E2 (PGE2) is responsible for inflammatory symptoms. However, PGE2 also suppresses pro-inflammatory cytokine production. There are at least 4 subtypes of PGE2 receptors, EP1-EP4, but it is unclear which of these specifically control cytokine production. The aim of this study was to determine which of the different receptors, EP1R-EP4R modulate production of tumor necrosis factor-α (TNF-α) in human monocytic cells. Human blood, or the human monocytic cell line THP-1 were stimulated with LPS. The actions of PGE2, alongside both selective agonists of EP1-EP4 receptors, were assessed on LPS-ind...
Source: Biochimica et Biophysica Acta - July 24, 2018 Category: Biochemistry Authors: Kashmiry A, Tate R, Rotondo G, Davidson J, Rotondo D Tags: Biochim Biophys Acta Source Type: research

LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling.
In conclusion, LAZ3 protects against cardiac remodeling in DCM by decreasing miR-21, thus regulating PPARa/NRF2 signaling. PMID: 30031228 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - July 18, 2018 Category: Biochemistry Authors: Gao L, Liu Y, Guo S, Xiao L, Wu L, Wang Z, Liang C, Yao R, Zhang Y Tags: Biochim Biophys Acta Source Type: research

Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.
In conclusion, our findings demonstrate that AGPAT2, which is mutated in patients with congenital generalized lipodystrophy and over-expressed in different types of cancer, is a direct transcriptional target of HIF-1, suggesting that upregulation of lipid storage by HIF-1 plays an important role in adaptation and survival of cancer cells under low oxygen conditions. PMID: 29908837 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - June 14, 2018 Category: Biochemistry Authors: Triantafyllou EA, Georgatsou E, Mylonis I, Simos G, Paraskeva E Tags: Biochim Biophys Acta Source Type: research

Lethal (2) giant larvae regulates pleural mesothelial cell polarity in pleural fibrosis.
In this study, we observed that PMC polarity was lost in fibrotic pleura. Next we found increased Lethal (2) giant larvae (Lgl) bound with aPKC and PAR-6B competing against PAR-3A in PAR complex, which led to cell polarity loss. Then we demonstrated that Lgl1 siRNA prevented cell polarity loss in PMCs, and Lgl1 conditional knockout (ER-Cre+/-Lgl1flox/flox) attenuated pleural fibrosis in a mouse model. Our data indicated that Lgl1 regulates cell polarity of PMCs, inhibition of Lgl1 and maintenance of cell polarity in PMCs could be a potential therapeutic treatment approach for pleural fibrosis. PMID: 29842893 [PubMed -...
Source: Biochimica et Biophysica Acta - May 26, 2018 Category: Biochemistry Authors: Song LJ, Zhou LL, Wang M, Liu F, Xiong L, Xiang F, Yu F, He XL, Xu JJ, Shi HZ, Xin JB, Ma WL, Ye H Tags: Biochim Biophys Acta Source Type: research