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Source: Biochimica et Biophysica Acta
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Total 177 results found since Jan 2013.
The interaction of CFLAR with p130Cas promotes cell migration
Biochim Biophys Acta Mol Cell Res. 2022 Nov 15:119390. doi: 10.1016/j.bbamcr.2022.119390. Online ahead of print.ABSTRACTCASP8 and FADD Like Apoptosis Regulator (CFLAR) is a key anti-apoptotic regulator for resistance to apoptosis mediated by Fas and TRAIL. In addition to its anti-apoptotic function, CFLAR is also an important mediator of tumor growth. High level of CFLAR expression correlates with a more aggressive tumor. However, the mechanism of CFLAR signaling in malignant progression is not clear. Here we report a novel CFLAR-associated protein p130Cas, which is a general regulator of cell growth and cell migration. CF...
Source: Biochimica et Biophysica Acta - November 18, 2022 Category: Biochemistry Authors: Hao Li Luqi Li Xun Qiu Jing Zhang Zichun Hua Source Type: research
Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension
CONCLUSIONS: Iron deficiency promoted oxidative stress and apoptosis in HPAECs in hypoxia-induced PH, and enhanced expression of hepcidin regulated by BMP6/BMPR2 signaling may contribute to iron metabolic disorder.PMID:36343841 | DOI:10.1016/j.bbadis.2022.166589
Source: Biochimica et Biophysica Acta - November 7, 2022 Category: Biochemistry Authors: Yujie Jiang Yingfan Guo Xuexiang Feng Pingting Yang Yi Liu Xuejing Dai Feilong Zhao Dongyu Lei Xiaohui Li Yuan Liu Ying Li Source Type: research
Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells
Biochim Biophys Acta Mol Cell Res. 2022 Sep 23:119361. doi: 10.1016/j.bbamcr.2022.119361. Online ahead of print.ABSTRACTPhospholipase D1 (PLD1) plays a crucial role in cell differentiation of different cell types. However, the involvement of PLD1 in astrocytic differentiation remains uncertain. In the present study, we investigate the possible role of PLD1 and its product phosphatidic acid (PA) in astrocytic differentiation of hippocampal neural stem/progenitor cells (NSPCs) from hippocampi of embryonic day 16.5 rat embryos. We showed that overexpression of PLD1 increased the expression level of glial fibrillary acidic pro...
Source: Biochimica et Biophysica Acta - September 26, 2022 Category: Biochemistry Authors: Min-Jeong Kang Nuri Jin Shin-Young Park Joong-Soo Han Source Type: research
The performance and perspectives of dendritic cell vaccines modified by immune checkpoint inhibitors or stimulants
Biochim Biophys Acta Rev Cancer. 2022 Jul 21:188763. doi: 10.1016/j.bbcan.2022.188763. Online ahead of print.ABSTRACTTherapeutic dendritic cell (DC) vaccines stimulate the elimination of tumor cells by the immune system. However, while antigen-specific T cell responses induced by DC vaccines are commonly observed, the clinical response rate is relatively poor, necessitating vaccine optimization. There is evidence that the suppression of DC function by immune checkpoints hinders the anti-tumor immune responses mediated by DC vaccines, ultimately leading to the immune escape of the tumor cells. The use of immune checkpoint i...
Source: Biochimica et Biophysica Acta - July 25, 2022 Category: Biochemistry Authors: Jiage Ding Yanyan Zheng Gang Wang Junnian Zheng Dafei Chai Source Type: research
Nuclear RAC1 is a modulator of the doxorubicin-induced DNA damage response
Biochim Biophys Acta Mol Cell Res. 2022 Jul 8:119320. doi: 10.1016/j.bbamcr.2022.119320. Online ahead of print.ABSTRACTRho GTPases like RAC1 are localized on the inner side of the outer cell membrane where they act as molecular switches that can trigger signal transduction pathways in response to various extracellular stimuli. Nuclear functions of RAC1 were identified that are related to mitosis, cell cycle arrest and apoptosis. Previously, we showed that RAC1 plays a role in the doxorubicin (Dox)-induced DNA damage response (DDR). In this context it is still unknown whether cytosolic RAC1 modulates the Dox-induced DDR or ...
Source: Biochimica et Biophysica Acta - July 11, 2022 Category: Biochemistry Authors: Rebekka Kitzinger Gerhard Fritz Christian Henninger Source Type: research
Dengue virus is involved in insulin resistance via the downregulation of IRS-1 by inducing TNF- α secretion
Biochim Biophys Acta Mol Basis Dis. 2022 Jun 22:166472. doi: 10.1016/j.bbadis.2022.166472. Online ahead of print.ABSTRACTDuring the epidemic, the individuals with underlying diseases usually have a higher rate of mortality. Diabetes is highly prevalent worldwide, making it a frequent comorbidity in dengue fever patients. Therefore, understanding the relationship between dengue virus (DENV) infection and diabetes is important. We first demonstrated that DENV-3 infection down-regulated the expression of IRS-1. In vitro, treatment of HepG2 cells with TNF-α inhibitors and siRNA proved that after DENV-3 infection in HepG2 cell...
Source: Biochimica et Biophysica Acta - June 25, 2022 Category: Biochemistry Authors: Xuling Liu Zuxin Liang Hongwei Duan Jianhai Yu Zhiran Qin Jingshu Li Li Zhu Qinghua Wu Weiwei Xiao Chenguang Shen Chengsong Wan Kefeng Wu Hua Ye Bao Zhang Wei Zhao Source Type: research
Inactivation of fatty acid amide hydrolase protects against ischemic reperfusion injury-induced renal fibrogenesis
Biochim Biophys Acta Mol Basis Dis. 2022 Jun 13:166456. doi: 10.1016/j.bbadis.2022.166456. Online ahead of print.ABSTRACTAlthough cannabinoid receptors (CB) are recognized as targets for renal fibrosis, the role of endogenous cannabinoid anandamide (AEA) and its primary hydrolytic enzyme, fatty acid amide hydrolase (FAAH), in renal fibrogenesis remains unclear. The present study used a mouse model of post-ischemia-reperfusion renal injury (PIR) to test the hypothesis that FAAH participates in the renal fibrogenesis. Our results demonstrated that PIR showed upregulated expression of FAAH in renal proximal tubules, accompani...
Source: Biochimica et Biophysica Acta - June 16, 2022 Category: Biochemistry Authors: Chaoling Chen Weili Wang Justin L Poklis Aron H Lichtman Joseph K Ritter Gaizun Hu Dengpiao Xie Ningjun Li Source Type: research
Kinesin-7 CENP-E is essential for chromosome alignment and spindle assembly of mouse spermatocytes
In this study, by combining the use of chemical inhibitors, siRNA-mediated gene knockdown, immunohistochemistry, and high-resolution microscopy, we have found that CENP-E inhibition results in chromosome misalignment and metaphase arrest in dividing spermatocyte during meiosis. Strikingly, we have revealed that CENP-E regulates spindle organization in metaphase I spermatocytes and cultured GC-2 spd cells. CENP-E depletion leads to spindle elongation, chromosome misalignment, and chromosome instability in spermatocytes. Together, these findings indicate that CENP-E mediates the kinetochore recruitment of BubR1, spindle asse...
Source: Biochimica et Biophysica Acta - June 9, 2022 Category: Biochemistry Authors: Zhen-Yu She Meng-Fei Xu Sun-Ying Jiang Ya-Lan Wei Source Type: research
