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Source: Biochimica et Biophysica Acta
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Total 177 results found since Jan 2013.
Autophagy regulates transforming growth factor β signaling and receptor trafficking
Biochim Biophys Acta Mol Cell Res. 2022 May 20:119284. doi: 10.1016/j.bbamcr.2022.119284. Online ahead of print.ABSTRACTTransforming growth factor beta (TGFβ) stimulates tumorigenesis by inducing epithelial to mesenchymal transition (EMT) and cell migration. TGFβ signaling is regulated by the endocytosis of cell surface receptors and their subcellular trafficking into the endo-lysosomal system. Here we investigated how autophagy, a cellular quality control network that delivers material to lysosomes, regulates TGFβ signaling pathways that induce EMT and cell migration. We impaired autophagy in non-small cell lung cancer...
Source: Biochimica et Biophysica Acta - May 23, 2022 Category: Biochemistry Authors: Charles B Trelford Gianni M Di Guglielmo Source Type: research
Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes
CONCLUSIONS: Specific Amino acids regulate Sestrin2 levels in an ATF4-dependent manner in C2C12 cells.GENERAL SIGNIFICANCE: The results of the present study indicate that amino acids regulate levels of Sestrin2, which might cause phenotypic alterations, including mTORC1 activity, in C2C12 cells.PMID:35597502 | DOI:10.1016/j.bbagen.2022.130174
Source: Biochimica et Biophysica Acta - May 21, 2022 Category: Biochemistry Authors: Ran Sawa Ayaka Ohnishi Maya Ohno Maika Nagata Ikumi Wake Yasuhiko Okimura Source Type: research
Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes
This study is the first to describe Nudt19 as regulator of hepatic lipid metabolism and potential mediator of NAFLD and T2D development.PMID:35367353 | DOI:10.1016/j.bbalip.2022.159153
Source: Biochimica et Biophysica Acta - April 3, 2022 Category: Biochemistry Authors: Sarah G örigk D Margriet Ouwens Tanja Kuhn Delsi Altenhofen Christian Binsch Mareike Damen Jenny Minh-An Khuong Katharina Kaiser Birgit Knebel Heike Vogel Annette Sch ürmann Alexandra Chadt Hadi Al-Hasani Source Type: research
A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca < sup > 2+ < /sup > signalling through IP < sub > 3 < /sub > receptors
In this study, PKM2 was identified as an inositol 1,4,5-trisphosphate receptor (IP3R)-interacting protein by mass spectrometry. The PKM2:IP3R interaction was further characterized by pull-down and co-immunoprecipitation assays, which showed that PKM2 interacted with all three IP3R isoforms. Moreover, fluorescence microscopy indicated that both IP3R and PKM2 localized at the endoplasmic reticulum. PKM2 binds to IP3R at a highly conserved 21-amino acid site (corresponding to amino acids 2078-2098 in mouse type 1 IP3R isoform). Synthetic peptides (denoted 'TAT-D5SD' and 'D5SD'), based on the amino acid sequence at this site, ...
Source: Biochimica et Biophysica Acta - January 13, 2022 Category: Biochemistry Authors: Andrew R Lavik Karen S McColl Fernanda O Lemos Martijn Kerkhofs Fei Zhong Michael Harr Daniela Schlatzer Kozo Hamada Katsuhiko Mikoshiba Francesco Crea Geert Bultynck Martin D Bootman Jan B Parys Clark W Distelhorst Source Type: research
Leukotriene C < sub > 4 < /sub > synthase is a novel PPAR γ target gene, and leukotriene C < sub > 4 < /sub > and D < sub > 4 < /sub > activate adipogenesis through cysteinyl LT1 receptors in adipocytes
In this study, we investigated the expression of LTC4S and production of CysLTs in murine adipocyte 3T3-L1 cells and their underlying regulatory mechanisms. Expression of LTC4S and production of LTC4 and CysLTs increased during adipogenesis, whereas siRNA-mediated suppression of LTC4S expression repressed adipogenesis by reducing adipogenic gene expression. The CysLT1 receptor, one of the two LTC4 receptors, was expressed in adipocytes. LTC4 and LTD4 increased the intracellular triglyceride levels and adipogenic gene expression, and their enhancement was suppressed by co-treatment with pranlukast, a CysLT1 receptor antagon...
Source: Biochimica et Biophysica Acta - December 30, 2021 Category: Biochemistry Authors: Ko Fujimori Saki Uno Kyohei Kuroda Chihiro Matsumoto Toko Maehara Source Type: research
Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy
Biochim Biophys Acta Mol Basis Dis. 2021 Dec 20:166326. doi: 10.1016/j.bbadis.2021.166326. Online ahead of print.ABSTRACTNormal cells depend on autophagy to maintain cellular homeostasis by recycling damaged organelles and misfolded proteins and degrading toxic agents. Similar to apoptosis, targeting autophagy has been under attention in cancer therapy. However, autophagy has both pro-survival and pro-death functions in tumors, and its targeting requires further elucidation. The current review focuses on using nanoparticles for targeting autophagy in cancer treatment. Nanocarriers can deliver autophagy regulators along wit...
Source: Biochimica et Biophysica Acta - December 23, 2021 Category: Biochemistry Authors: Mahshid Deldar Abad Paskeh Maliheh Entezari Courtney Clark Amirhossein Zabolian Ehsan Ranjbar Mahdi Vasheghani Farahani Hossein Saleki Seyed Omid Sharifzadeh Fatemeh Bakhtiari Far Milad Ashrafizadeh Saeed Samarghandian Haroon Khan Saeid Ghavami Ali Zarrab Source Type: research
Deficiency of M-LP/Mpv17L leads to development of β-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-β pathways
In this study, we found that M-LP/Mpv17L-KO mice developed β-cell hyperplasia and improved glucose tolerance. Deficiency of M-LP/Mpv17L in islets from KO mice at early postnatal stages or siRNA-mediated suppression of M-LP/Mpv17L in rat insulinoma cells led to marked upregulation of lymphoid enhancer binding factor 1 (Lef1) and transcription factor 7 (Tcf7), key nuclear effectors in the Wnt signaling pathway, and some of the factors essential for the development and maintenance of β-cells. Moreover, at the protein level, increases in the levels of phosphorylated β-catenin and glycogen synthase kinase-3β (GSK-3β) were ...
Source: Biochimica et Biophysica Acta - December 9, 2021 Category: Biochemistry Authors: Reiko Iida Misuzu Ueki Toshihiro Yasuda Source Type: research
Therapeutic DNA vaccine encoding CEMIP (KIAA1199) ameliorates kidney fibrosis in obesity through inhibiting the Wnt/ β-catenin pathway
CONCLUSION: DNA vaccine targeting CEMIP/Wnt1/β-catenin pathway plays a novel strategy in nephropathy.GENERAL SIGNIFICANCE: Immune therapy might provide a new therapeutic option on nephropathy of obesity.PMID:34582938 | DOI:10.1016/j.bbagen.2021.130019
Source: Biochimica et Biophysica Acta - September 28, 2021 Category: Biochemistry Authors: Chao-Hung Chen Guan-Ming Ke Pi-Chen Lin Kun-Der Lin Source Type: research
