Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes

CONCLUSIONS: Specific Amino acids regulate Sestrin2 levels in an ATF4-dependent manner in C2C12 cells.GENERAL SIGNIFICANCE: The results of the present study indicate that amino acids regulate levels of Sestrin2, which might cause phenotypic alterations, including mTORC1 activity, in C2C12 cells.PMID:35597502 | DOI:10.1016/j.bbagen.2022.130174

Source: Biochimica et Biophysica Acta - May 21, 2022 Category: Biochemistry Authors: Ran Sawa Ayaka Ohnishi Maya Ohno Maika Nagata Ikumi Wake Yasuhiko Okimura Source Type: research