Lethal (2) giant larvae regulates pleural mesothelial cell polarity in pleural fibrosis.

In this study, we observed that PMC polarity was lost in fibrotic pleura. Next we found increased Lethal (2) giant larvae (Lgl) bound with aPKC and PAR-6B competing against PAR-3A in PAR complex, which led to cell polarity loss. Then we demonstrated that Lgl1 siRNA prevented cell polarity loss in PMCs, and Lgl1 conditional knockout (ER-Cre+/-Lgl1flox/flox) attenuated pleural fibrosis in a mouse model. Our data indicated that Lgl1 regulates cell polarity of PMCs, inhibition of Lgl1 and maintenance of cell polarity in PMCs could be a potential therapeutic treatment approach for pleural fibrosis.
PMID: 29842893 [PubMed - as supplied by publisher]

Source: Biochimica et Biophysica Acta - May 26, 2018 Category: Biochemistry Authors: Song LJ, Zhou LL, Wang M, Liu F, Xiong L, Xiang F, Yu F, He XL, Xu JJ, Shi HZ, Xin JB, Ma WL, Ye H Tags: Biochim Biophys Acta Source Type: research