Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways.
CONCLUSION: The loss of DUSP3 activity markedly increases gamma radiation-induced DNA strand breaks, suggesting a potential novel role for DUSP3 in DNA repair.
GENERAL SIGNIFICANCE: The radioresistance of tumor cells is effectively reduced by a combination of approaches through the inhibition of DUSPs.
PMID: 28389334 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Torres TE, Russo LC, Santos A, Marques GR, Magalhaes YT, Tabassum S, Forti FL Tags: Biochim Biophys Acta Source Type: research