Extracellular RNAs/TLR3 signaling contributes to acute intestinal injury induced by intestinal ischemia reperfusion in mice

In conclusion, exRNAs/TLR3 signaling is a key mechanism that regulates intestinal I/R injury in adult mice, and the TLR3/dsRNA complex inhibitor can be an effective approach for attenuating intestinal I/R-induced inflammatory response and apoptosis.PMID:37336369 | DOI:10.1016/j.bbadis.2023.166790

Source: Biochimica et Biophysica Acta - June 19, 2023 Category: Biochemistry Authors: Yu-Qiong Lei Yan-Tong Wan Guang-Tao Liang Yu-Hao Huang Peng Dong Si-Dan Luo Wen-Juan Zhang Wei-Feng Liu Ke-Xuan Liu Xi-Yang Zhang Source Type: research