G9a and DNMT1 inhibition modulates CDKN1A promoter methylation and the cell cycle leading to improvement in kidney fibrosis

CONCLUSIONS: Our data link G9a and DNMT1 to CDKN1A regulatory function and kidney fibrosis. Combined targeting G9a and DNMT1 could be a promising strategy for the treatment of kidney fibrosis.PMID:37356504 | DOI:10.1016/j.bbagen.2023.130417
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research