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Source: BMC Cancer

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Total 95 results found since Jan 2013.

MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells
Conclusion: The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation, which would be helpful in developing miRNA-based treatments for ESCC.
Source: BMC Cancer - January 31, 2015 Category: Cancer & Oncology Authors: Tingting YuRisheng CaoShuo LiMingen FuLihua RenWeixu ChenHong ZhuQiang ZhanRuihua Shi Source Type: research

Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer
Conclusions: These results suggest that SMC1A plays an essential role in the development of CRC and may be a predictive factor in patients with CRC. The inhibition of SMC1A may serve as a promising therapeutic strategy for human CRC.
Source: BMC Cancer - March 4, 2015 Category: Cancer & Oncology Authors: Jianwei WangShaojun YuLiming CuiWenhui WangJun LiKe WangXinyuan Lao Source Type: research

Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways
Conclusions: TK1 was responsible for anticancer activity of dT-QX while levels of TYMP counteracted such an activity. The counteraction by TYMP could be overcome with RNA silencing to significantly enhance the dT-QX selectivity in cancer cells.
Source: BMC Cancer - March 21, 2015 Category: Cancer & Oncology Authors: Qiong WeiHaijuan LiuHonghao ZhouDejun ZhangZhiwei ZhangQibing Zhou Source Type: research

The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion
Conclusions: These results suggest that IMP3 facilitates PDAC progression by enhancing the pro-metastatic behaviour of tumour cells.
Source: BMC Cancer - April 11, 2015 Category: Cancer & Oncology Authors: Clarissa PasiliaoChe-Wei ChangBrent SutherlandShannon ValdezDavid SchaefferDonald YappSylvia Ng Source Type: research

Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck
Conclusions: Our findings suggest that WT1 and p63 act as oncogenes in SCCHN, affecting multiple genes involved in cancer cell growth.
Source: BMC Cancer - May 1, 2015 Category: Cancer & Oncology Authors: Xingru LiSofia OttossonSihan WangEmma JernbergLinda BoldrupXiaolian GuKarin NylanderAihong Li Source Type: research

High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy
Conclusions: KPNA2 is a novel independent prognostic marker for bladder recurrence, DFS and OS of UTUC patients who have undergone RNU. Moreover, these data suggest that KPNA2 may be a promising therapeutic target for UTUC.
Source: BMC Cancer - May 9, 2015 Category: Cancer & Oncology Authors: Bentao ShiBoxing SuDong FangYuan TangGengyan XiongZhongqiang GuoQun HeXinyu YangWei ZhaoYinglu GuoXuesong LiLiqun Zhou Source Type: research

Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun genes
In this study, we aimed to explore the role of MSK1 in Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1)-promoted carcinogenesis of nasopharyngeal carcinoma (NPC). Methods: The level of MSK1 phosphorylation at Thr581 was detected by the immunohistochemical analysis in NPC tissues and normal nasopharynx tissues, and its correlation with LMP1 was analyzed in NPC tissues and cell lines. Using MSK1 inhibitor H89 or small interfering RNA (siRNA)-MSK1, the effects of MSK1 on LMP1-promoted CNE1 cell proliferation and transformation were evaluated by CCK-8 assay, flow cytometry and focus-forming assay respectively. Further...
Source: BMC Cancer - May 10, 2015 Category: Cancer & Oncology Authors: Binbin LiZheng WanGuoliang HuangZunnan HuangXiangning ZhangDan LiaoShengqun LuoZhiwei He Source Type: research

Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
Conclusions: Together, these data highlight a broader role for dysregulated MAPK7 in driving tumorigenesis within niche populations of highly prevalent tumor types, and describe current efforts in establishing a robust drug discovery screening cascade.
Source: BMC Cancer - June 4, 2015 Category: Cancer & Oncology Authors: Paul GavineMei WangDehua YuEva HuChunlei HuangJenny XiaXinying SuJoan FanTianwei ZhangQingqing YeLi ZhengGuanshan ZhuZiliang QianQingquan LuoYing HouQunsheng Ji Source Type: research

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes
Conclusions: Our data suggest that the truncated PPARα splice variant functions as an endogenous inhibitor of proliferative and pro-inflammatory genes in human cells and that its absence in mouse may explain species-specific differences in fibrate-induced hepatocarcinogenesis.
Source: BMC Cancer - June 30, 2015 Category: Cancer & Oncology Authors: Maria ThomasChristine BayhaKathrin KleinSimon MüllerThomas WeissMatthias SchwabUlrich Zanger Source Type: research

P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement
Conclusion: P-gp over-expression is a possible mechanism of acquired resistance to 17-DMAG in cells with ALK rearrangement.
Source: BMC Cancer - July 29, 2015 Category: Cancer & Oncology Authors: Hee KimKye LeeYoung KimYun ChoiJung-Eun LeeChang ChoiIn-Jeoung BaekJin RhoJae Lee Source Type: research

Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells
Conclusions: Evidence of EV-mediated induction of malignant phenotype, and reversal of malignant phenotype, provides rational basis for further study of the role of EVs in tumorigenesis. Identification of 14-3-3 zeta/delta as up-regulated in malignancy suggests its potential as a putative drug target for the treatment of colorectal cancer.
Source: BMC Cancer - August 1, 2015 Category: Cancer & Oncology Authors: Hillary MulveyAudrey ChangJason AdlerMichael Del TattoKimberly PerezPeter QuesenberryDevasis Chatterjee Source Type: research

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13
Conclusions: We show that the PKA-anchoring protein AKAP13 is essential for the phosphorylation of ERαS305, which leads to tamoxifen resistance both in cell lines and tamoxifen-treated breast cancer patients.
Source: BMC Cancer - August 14, 2015 Category: Cancer & Oncology Authors: Cristiane Bentin ToaldoXanthippi AlexiKarin BeelenMarleen KokMichael HauptmannMaurice JansenEls BernsJacques NeefjesSabine LinnRob MichalidesWilbert Zwart Source Type: research

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy
Background: Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemotherapy-induced MRP1 expression Notch in breast cancers, and whether this pathway can be manipulated with an inhibitor of Notch activity. Methods: MRP1 and Notch1 were investigated in 29 patients treated with neoadjuvant chemotherapy (NAC) for breast cancer, using immunohistochemistry on matched biopsy (pre-N...
Source: BMC Cancer - September 11, 2015 Category: Cancer & Oncology Authors: Baek KimSam StephenAndrew HanbyKieran HorganSarah PerryJulie RichardsonElizabeth RoundhillElizabeth ValleleyEldo VergheseBethany WilliamsJames ThorneThomas Hughes Source Type: research

Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells
Background: Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis. Posttranslational regulation of HIF-1α is dependent on Prolyl hydroxylase (PHD 1–3) and Factor Inhibiting HIF (FIH) hydroxylase enzymes, which require ascorbic acid as a co-factor for optimal function. Depleted intra-tumoral ascorbic acid may thus play a role in the loss of HIF-1α regulation in melanoma. These studies assess the ability of ascorbic acid to reduce HIF-1α protein and transcriptional activity in metastatic melanoma and reduce its invasive potential. Methods: HIF-1α protein was evaluated by wester...
Source: BMC Cancer - November 7, 2015 Category: Cancer & Oncology Authors: Sarah MilesAdam FischerSandeep JoshiRichard Niles Source Type: research

Neuropilin-2 induced by transforming growth factor-β augments migration of hepatocellular carcinoma cells
Conclusions: These data suggest that NRP2 associates with a less differentiated, mesenchymal-like HCC phenotype and that NRP2 plays an important role in tumor cell migration upon TGF-β-dependent HCC progression.
Source: BMC Cancer - November 16, 2015 Category: Cancer & Oncology Authors: Philipp WittmannMarkus GrubingerChristian GrögerHeidemarie HuberWolfgang SieghartMarkus Peck-RadosavljevicWolfgang Mikulits Source Type: research