Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells

Conclusions: Evidence of EV-mediated induction of malignant phenotype, and reversal of malignant phenotype, provides rational basis for further study of the role of EVs in tumorigenesis. Identification of 14-3-3 zeta/delta as up-regulated in malignancy suggests its potential as a putative drug target for the treatment of colorectal cancer.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Source Type: research