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Source: BMC Cancer

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Total 95 results found since Jan 2013.

B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells
Conclusions: The current study demonstrated the oncogenic property of BCL6 in breast cancer and further study could target BCL6 as a novel potential therapeutic strategy for breast cancer.
Source: BMC Cancer - June 10, 2014 Category: Cancer & Oncology Authors: Qiang WuXue LiuHong YanYin-huan HeShan YeXing-wang ChengGui-lu ZhuWen-yong WuXiao-nan WangXiang-jun KongXiao-chun XuPeter LobieTao ZhuZheng-sheng Wu Source Type: research

Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells
Conclusion: The results demonstrate LPA-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR transactivation.
Source: BMC Cancer - June 13, 2014 Category: Cancer & Oncology Authors: Ingvild BrusevoldIngun TveteraasMonica AasrumJohn ØdegårdDagny SandnesThoralf Christoffersen Source Type: research

KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer
Background: Kinesin family member 2a (KIF2A), a type of motor protein found in eukaryotic cells, is associated with development and progression of various human cancers. The role of KIF2A during breast cancer tumorigenesis and progression was studied. Methods: Immunohistochemical staining, real time RT-PCR and western blot were used to examine the expression of KIF2A in cancer tissues and adjacent normal tissues from breast cancer patients. Patients' survival in relation to KIF2A expression was estimated using the Kaplan-Meier survival and multivariate analysis. Breast cancer cell line, MDA-MB-231 was used to study the pro...
Source: BMC Cancer - June 21, 2014 Category: Cancer & Oncology Authors: Jianli WangSiqin MaRong MaXun QuWenjun LiuCuixia LvSong ZhaoYunyun Gong Source Type: research

IL-1beta mediates MCP-1 induction by Wnt5a in gastric cancer cells
Conclusions: These results suggest that Wnt5a is involved in macrophage recruitment by upregulating MCP-1, and IL-1Ra may be used to inhibit macrophage recruitment in gastric cancer.
Source: BMC Cancer - July 3, 2014 Category: Cancer & Oncology Authors: Shengjun LiWei WangNing ZhangTingxian MaChenghai Zhao Source Type: research

Ionizing radiation induces tumor cell lysyl oxidase secretion
Conclusions: These results indicate a differential regulation of LOX-expression and secretion in response to IR and hypoxia, and suggest that LOX may contribute towards an IR-induced migratory phenotype in sublethally-irradiated tumor cells and tumor progression.
Source: BMC Cancer - July 22, 2014 Category: Cancer & Oncology Authors: Colette ShenAshish SharmaDinh-Van VuongJanine ErlerMartin PruschyAngela Broggini-Tenzer Source Type: research

DeltaNp63alpha enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2
Conclusions: Here, we report that GLI2 is the novel target gene of DeltaNp63alpha and that DeltaNp63alpha-GLI2 crosstalk in osteosarcoma cells is a necessary event in osteosarcoma progression. Defining the exact mechanisms involved in this interaction that mediate the pathogenesis of osteosarcoma promises to identify targets for drug therapy.
Source: BMC Cancer - August 1, 2014 Category: Cancer & Oncology Authors: Ram Mohan Ram KumarMichael BetzBernhard RoblWalter BornBruno Fuchs Source Type: research

CDK11p58 inhibits ERalpha-positive breast cancer invasion by targeting integrin beta3 via the repression of ERalpha signaling
Conclusions: These data indicate that CDK11p58 is an anti-metastatic gene in ERalpha-positive breast cancer and that the regulation of integrin beta3 by CDK11p58 via the repression of ERalpha signaling may constitute part of a signaling pathway underlying breast cancer invasion.
Source: BMC Cancer - August 8, 2014 Category: Cancer & Oncology Authors: Yayun ChiSheng HuangLei WangRuoji ZhouLisha WangXiuying XiaoDali LiYing CaiXiaoyan ZhouJiong Wu Source Type: research

Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma
Conclusions: Our in vitro analyses show that MIF functions upstream of the PI3K/Akt pathway in human melanoma cell lines. Moreover, depletion of MIF inhibited melanoma proliferation, viability and clonogenic capacity. Clinically, high MIF levels in metastatic melanoma were found to be associated with faster disease recurrence. These findings support the clinical significance of MIF signalling in melanoma and provide a strong rationale for both targeting and monitoring MIF expression in clinical melanoma.
Source: BMC Cancer - August 29, 2014 Category: Cancer & Oncology Authors: Camila OliveiraCharles de BockTimothy MolloyElham SadeqzadehXin Yan GengPeter HerseyXu Dong ZhangRick Thorne Source Type: research

Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor
Background: The urokinase-type plasminogen activator receptor (uPAR) is an important regulator of ECM proteolysis, cell-ECM interactions and cell signaling. uPAR and heat shock proteins HSP70 and MRJ (DNAJB6) have been implicated in tumor growth and metastasis. We have reported recently that MRJ (DNAJB6, a heat shock protein) can interact with uPAR and enhance cell adhesion. Here, we identified another heat shock protein HSP70 as a novel uPAR-interacting protein. Methods: We performed co-immunoprecipitation in human embryonic kidney (HEK) 293 and colon cancer HCT116 cells as well as immunofluorence assays in HEK293 cells s...
Source: BMC Cancer - August 30, 2014 Category: Cancer & Oncology Authors: Yuli LinNana PengHongqin ZhuangDi ZhangYao WangZi-Chun Hua Source Type: research

microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18
Conclusions: We demonstrated that miR-30b/c was down-regulated in NSCLC specimens compared with adjacent non-tumor tissues. miR-30b/c directly targeted and down-regulated Rab18 expression and inhibited NSCLC cells proliferation. These data indicated that miR-30b/c could serve as a tumor suppressor gene involved in NSCLC pathogenesis.
Source: BMC Cancer - September 24, 2014 Category: Cancer & Oncology Authors: Keng ZhongKun ChenLin HanBailing Li Source Type: research

Tumor suppressor micro RNA miR-145 and onco micro RNAs miR-21 and miR-222 expressions are differentially modulated by Hepatitis B virus X protein in malignant hepatocytes
Conclusion: Thus, HBx protein differentially modulated the expression of miRNAs. The study throws light into possible way by which HBx protein acts through microRNA and thereby regulate host functioning. It might suggest new therapeutic strategies against hepatic cancer.
Source: BMC Cancer - September 26, 2014 Category: Cancer & Oncology Authors: Manikankana BandopadhyayArup BanerjeeNeelakshi SarkarRajesh PanigrahiSibnarayan DattaAnanya PalShivram SinghAvik BiswasShekhar ChakrabartiRunu Chakravarty Source Type: research

CUB Domain Containing Protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells
Conclusions: A number of recent studies have assigned a potentially important role for the cell-surface protein CDCP1 in invasion and metastasis of a several types of human cancer cells. In this study, CDCP1 was shown to modulate cell-substratum adhesion and motility in colon cancer cell lines, with some variation depending on the colon cancer cell type. CDCP1 and CD9 were co-expressed at the mRNA and protein level and we obtained evidence for the presence of a molecular complex of these proteins in SW480 colon cancer cells.
Source: BMC Cancer - October 9, 2014 Category: Cancer & Oncology Authors: David Orchard-WebbThong LeeGraham CookG Blair Source Type: research

Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer
Conclusions: The present study shows that elevated EET levels in BC tissues are associated with upregulation of CYP2C8, 2C9, and 2J2, and downregulation of sEH, and are also associated with aggressive cell behavior in BC patients.
Source: BMC Cancer - November 18, 2014 Category: Cancer & Oncology Authors: Xiaolong WeiDonghong ZhangXiaowei DouNa NiuWenhe HuangJingwen BaiGuo-Jun Zhang Source Type: research

Triple negative breast cancers express receptors for LHRH and are potential therapeutic targets for cytotoxic LHRH-analogs, AEZS 108 and AEZS 125
Conclusion: The current study confirms that LHRH-receptors are expressed by a significant proportion of TNBC and can be successfully used as homing sites for cytotoxic analogs of LHRH, such as AEZS-108 and AEZS-125.
Source: BMC Cancer - November 19, 2014 Category: Cancer & Oncology Authors: Stephan SeitzStefan BuchholzAndrew SchallyFlorian WeberMonika Klinkhammer-SchalkeElisabeth InwaldRoberto PerezFerenc RickLuca SzalontayFlorian HohlaSabine SegererChui KwokOlaf OrtmannJörg Engel Source Type: research

Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation
Conclusions: We demonstrate a cross-talk between alpha1D-AR and TRPV1, that is involved in the control of PC3 cell proliferation. These data strongly support for a putative novel pharmacological approach in the treatment of PCa by targeting both alpha1D-AR and TRPV1 channels.
Source: BMC Cancer - December 7, 2014 Category: Cancer & Oncology Authors: Maria MorelliConsuelo AmantiniMassimo NabissiSonia LiberatiClaudio CardinaliValerio FarfarielloDaniele TomassoniWilma QuagliaAlessandro PiergentiliAlessandro BonifaziFabio Del BelloMatteo SantoniGabriele MammanaLucilla ServiAlessandra FilosaAngela Gismond Source Type: research