DeltaNp63alpha enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2
Conclusions:
Here, we report that GLI2 is the novel target gene of DeltaNp63alpha and that DeltaNp63alpha-GLI2 crosstalk in osteosarcoma cells is a necessary event in osteosarcoma progression. Defining the exact mechanisms involved in this interaction that mediate the pathogenesis of osteosarcoma promises to identify targets for drug therapy.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Ram Mohan Ram KumarMichael BetzBernhard RoblWalter BornBruno Fuchs Source Type: research
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