CDK11p58 inhibits ERalpha-positive breast cancer invasion by targeting integrin beta3 via the repression of ERalpha signaling

Conclusions:
These data indicate that CDK11p58 is an anti-metastatic gene in ERalpha-positive breast cancer and that the regulation of integrin beta3 by CDK11p58 via the repression of ERalpha signaling may constitute part of a signaling pathway underlying breast cancer invasion.

Source: BMC Cancer - August 8, 2014 Category: Cancer & Oncology Authors: Yayun ChiSheng HuangLei WangRuoji ZhouLisha WangXiuying XiaoDali LiYing CaiXiaoyan ZhouJiong Wu Source Type: research