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Source: BMC Cancer

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Total 95 results found since Jan 2013.

DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines
Conclusions: We identified DKK1 as a possible marker of a cisplatin-refractory phenotype and as a potential novel therapeutic target to improve platinum response of NSCLC cells.
Source: BMC Cancer - September 9, 2015 Category: Cancer & Oncology Authors: Hogir SalimDali ZongPetra HåågMetka NovakBirgitta MörkRolf LewensohnLovisa LundholmKristina Viktorsson Source Type: research

CA1 contributes to microcalcification and tumourigenesis in breast cancer
Conclusion: The results of this study suggested that CA1 is a potential oncogene and that it contributes to abnormal cell calcification, apoptosis and migration in breast cancer.
Source: BMC Cancer - October 12, 2015 Category: Cancer & Oncology Authors: Yabing ZhengBing XuYan ZhaoHe GuChang LiYao WangXiaotian Chang Source Type: research

Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer
Conclusions: Our findings support the role of MIF in tumor aggressiveness and suggest its potential application as a therapeutic target for gallbladder cancer.
Source: BMC Cancer - November 4, 2015 Category: Cancer & Oncology Authors: Tejaswini SubbannayyaPamela Leal-RojasMustafa BarbhuiyaRemya RajaSantosh RenuseGajanan SatheSneha PintoNazia SyedVishalakshi NanjappaArun PatilPatricia GarciaNandini SahasrabuddheBipin NairRafael Guerrero-PrestonSanjay NavaniPramod TiwariVani SantoshDavid Source Type: research

Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells
Conclusions: Taken together, this work presents the novel anticancer candidate WZ35 for the treatment of prostate cancer, and importantly, reveals that increased ROS generation might be an effective strategy in human prostate cancer treatment.
Source: BMC Cancer - November 6, 2015 Category: Cancer & Oncology Authors: Xiuhua ZhangMinxiao ChenPeng ZouKarvannan KanchanaQiaoyou WengWenbo ChenPeng ZhongJiansong JiHuiping ZhouLangchong HeGuang Liang Source Type: research

MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer
Conclusions: These findings demonstrate that the overexpression of miR-363 reduces cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN.
Source: BMC Cancer - November 6, 2015 Category: Cancer & Oncology Authors: Bhavana ChapmanAbigail WaldParvez AkhtarAna MunkoJingjing XuSandra GibsonJennifer GrandisRobert FerrisSaleem Khan Source Type: research

Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines
Conclusions: This discrepancy between the effects of Rac3 knockdown in the two cell lines could be explained as follows: in the MDA-MB-231 line, the Rac3-dependent aggressiveness of the cancer cells is due to the Rac3/ERK-2/NF-kappaB signaling pathway, which is responsible for MMP-9, interleukin-6, -8 and GRO secretion, as well as the resistance to TNF-induced apoptosis, whereas in the MCF-7 line, this pathway is not functional because of the low expression of NF-kappaB subunits in these cells. Rac3 may be a potent target for inhibiting aggressive breast cancer.
Source: BMC Cancer - February 6, 2013 Category: Cancer & Oncology Authors: Caroline GestUlrich JoimelLimin HuangLinda-Louise PritchardAlexandre PetitCharlène DulongCatherine BuquetChao-Quan HuPezhman MirshahiMarc LaurentFrançoise Fauvel-LafèveLionel CazinJean-Pierre VannierHe LuJeannette SoriaHong LiRémi VarinClaudine Soria Source Type: research

Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-beta
Conclusions: The results suggest that imatinib mesylate may be useful in the treatment of MPNST patients and in vitro studies may help select cells that are sensitive to imatinib mesylate in vivo.
Source: BMC Cancer - May 4, 2013 Category: Cancer & Oncology Authors: Jun OhishiMikiko AokiKazuki NabeshimaJunji SuzumiyaTamotsu TakeuchiAkira OgoseMichiyuki HakozakiYuichi YamashitaHiroshi Iwasaki Source Type: research

The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma
Conclusion: Notch1 may induce a migratory effect in ICC by causing an epithelial-mesenchymal transition and activating Rac1 and could serve as a novel diagnostic and therapeutic target in patients with ICC.
Source: BMC Cancer - May 20, 2013 Category: Cancer & Oncology Authors: Qi ZhouYafeng WangBaogang PengLijian LiangJiaping Li Source Type: research

Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2
Conclusion: Our study indicates that GnRH-II agonist promoted cell motility of endometrial cancer cells through the GnRH-I receptor via the phosphorylation of ERK1/2 and JNK, and the subsequent, MAPK-dependent activation of MMP-2. Our findings represent a new concept regarding the mechanism of GnRH-II-induced cell motility in endometrial cancer cells and suggest the possibility of exploring GnRH-II as a potential therapeutic target for the treatment of human endometrial cancer.
Source: BMC Cancer - June 20, 2013 Category: Cancer & Oncology Authors: Hsien-Ming WuHsin-Shih WangHong-Yuan HuangChyong-Huey LaiChyi-Long LeeYung-Kuei SoongPeter Leung Source Type: research

The cysteinyl leukotriene 2 receptor contributes to all-trans retinoic acid-induced differentiation of colon cancer cells
Conclusions: This study identifies a novel mechanism of action for ATRA in colorectal cancer cell differentiation and demonstrates that retinoids can have anti-tumorigenic effects through their action on the cysteinyl leukotriene pathway.
Source: BMC Cancer - July 8, 2013 Category: Cancer & Oncology Authors: Astrid BengtssonGunilla JönssonCecilia MagnussonTavga SalimCecilia AxelssonAnita Sjölander Source Type: research

Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer
Conclusions: We therefore conclude that abnormal Pygo2 protein expression may be a marker for advanced NSCLC. Furthermore, Pygo2 knockdown suppresses cell growth.
Source: BMC Cancer - July 16, 2013 Category: Cancer & Oncology Authors: Yang LiuQian-Ze DongSi WangChang-Qing FangYuan MiaoLiang WangMing-Zhu LiEn-Hua Wang Source Type: research

Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses
The circadian clock and cell cycle are two global regulatory systems that have pervasive behavioral and physiological effects on eukaryotic cells, and both play a role in cancer development. Recent studies have indicated that the circadian and cell cycle regulator, TIMELESS, may serve as a molecular bridge between these two regulatory systems. To assess the role of TIMELESS in tumorigenesis, we analyzed TIMELESS expression data from publically accessible online databases. A loss-of-function analysis was then performed using TIMELESS-targeting siRNA oligos followed by a whole-genome expression microarray and network analysi...
Source: BMC Cancer - October 25, 2013 Category: Cancer & Oncology Authors: Yingying MaoAlan FuDerek LeadererTongzhang ZhengKun ChenYong Zhu Source Type: research

Evaluation of a curcumin analog as an anti-cancer agent inducing ER stress-mediated apoptosis in non-small cell lung cancer cells
Conclusions: A new monocarbonyl analog of curcumin, B82, exhibited anti-tumor effects on H460 cells via an ER stress-mediated mechanism. B82 could be further explored as a potential anticancer agent for the treatment of NSCLC.
Source: BMC Cancer - October 24, 2013 Category: Cancer & Oncology Authors: Zhiguo LiuYusheng SunLuqing RenYi HuangYuepiao CaiQiaoyou WengXueqian ShenXiaokun LiGuang LiangYi Wang Source Type: research

Wnt signaling in triple negative breast cancer is associated with metastasis
Conclusion: These data implicate transcriptional Wnt signaling as a hallmark of TNBC disease associated with specific metastatic pathways.
Source: BMC Cancer - November 10, 2013 Category: Cancer & Oncology Authors: Nandini DeyBenjamin BarwickCarlos MorenoMaja Ordanic-KodaniZhengjia ChenGabriella Oprea-IliesWeining TangCharles CatzavelosKimberly KerstannGeorge SledgeMark AbramovitzMark BouzykPradip DeBrian Leyland-Jones Source Type: research

Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival
Conclusion: Breast cancers with high DSS1 expression have worse prognosis and shorter relapse-free survival times. DSS1 is necessary to rescue cells from DNA damage, but high DSS1 expression increases drug resistance. We suggest that DSS1 expression could be a useful marker for drug resistance in breast cancers, and DSS1 knockdown can induce tumor apoptosis when used in combination with DNA-damaging drugs.
Source: BMC Cancer - December 1, 2013 Category: Cancer & Oncology Authors: Andri RezanoKazuhiko KuwaharaMutsuko Yamamoto-IbusukiMasahiro KitabatakePenpak MoolthiyaSuchada PhimsenTaiji SudaShigenobu ToneYutaka YamamotoHirotaka IwaseNobuo Sakaguchi Source Type: research