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Source: BMC Cancer

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Total 95 results found since Jan 2013.

Superparamagnetic iron oxide nanoparticles mediated 131I-hVEGF siRNA inhibits hepatocellular carcinoma tumor growth in nude mice
Conclusions: EMF-guided 131I-hVEGF siRNA/SilenceMag exhibited an antitumor effect. The synergic therapy of 131I-hVEGF siRNA/SilenceMag might be a promising future treatment option against HCC with the dual functional properties of tumor therapy and imaging.
Source: BMC Cancer - February 21, 2014 Category: Cancer & Oncology Authors: Jing ChenShu ZhuLiangqian TongJiansha LiFei ChenYunfeng HanMing ZhaoWei Xiong Source Type: research

Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes
Conclusions: Our results indicate that the metabolic defects introduced by siRNA silencing of metabolic enzymes TKT or AK2 may be compensated by alternative feedback metabolic mechanisms, suggesting that cancer cells may overcome single defective pathways through secondary metabolic network adaptations. The highly robust nature of oral cancer cell metabolism implies that a systematic medical approach targeting multiple metabolic pathways may be needed to accomplish the continued improvement of cancer treatment.
Source: BMC Cancer - March 25, 2014 Category: Cancer & Oncology Authors: Min ZhangYang ChaiJeffrey BrumbaughXiaojun LiuRamin RabiiSizhe FengKaori MisunoDiana MessadiShen Hu Source Type: research

The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells
Conclusions: The findings of this study demonstrate that ROCK-1 protein plays a key role in regulating metastasis and invasion of Y79 cells, suggesting that the ROCK-1 dependent pathway may be a potential target for therapy of Rb.
Source: BMC Cancer - February 14, 2014 Category: Cancer & Oncology Authors: Jing WangXiao-Hong LiuZi-Jian YangBing XieYi-Sheng Zhong Source Type: research

Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells
Conclusions: These results suggest that, while Wee1 acts as a tumor suppressor in the context of normal cell growth and its functional loss can be compensated by p53-dependent DNA damage repairing mechanisms, specific inhibition of Wee1 has deleterious effects on the proliferation and survival of p53 inactive tumors. In total, targeting the atypical kinase Wee1 with an siRNA-based therapeutic or a selective ATP competitive small molecule inhibitor would be a feasible approach to targeting p53 inactive tumors in the clinic.
Source: BMC Cancer - June 13, 2014 Category: Cancer & Oncology Authors: William PappanoQian ZhangLora TuckerChris TseJieyi Wang Source Type: research

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
Conclusions: Overall, these results suggest that further investigation of CDK1 inhibition as a potential therapy for MYC-dependent breast cancer is warranted.
Source: BMC Cancer - January 20, 2014 Category: Cancer & Oncology Authors: Jian KangC SergioRobert SutherlandElizabeth Musgrove Source Type: research

Sox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity
Conclusion: Sox2 regulates the invasiveness of BC cells via a mechanism that is dependent on Twist1 and the transcriptional status of Sox2. Our results have further highlighted a new level of biological complexity and heterogeneity of BC cells that may carry significant clinical implications.
Source: BMC Cancer - July 1, 2013 Category: Cancer & Oncology Authors: Fang WuXiaoxia YePeng WangKaren JungChengsheng WuDonna DouglasNorman KnetemanGilbert BigrasYupo MaRaymond Lai Source Type: research

HRG-beta1-driven ErbB3 signaling induces epithelial--mesenchymal transition in breast cancer cells
Conclusions: Our data suggest that HRG-beta1 and ErbB3 induce EMT, cancer cell migration and invasion through the PI3k/Akt-phospho-Smad2-Snail signaling pathway in SK-BR-3 and MCF7 breast cancer cells.
Source: BMC Cancer - August 12, 2013 Category: Cancer & Oncology Authors: Jinkyoung KimHoiseon JeongYoungseok LeeChungyeul KimHankyeom KimAeree Kim Source Type: research

HRG-ß1-driven ErbB3 signaling induces epithelial¿mesenchymal transition in breast cancer cells
Conclusions: Our data suggest that HRG-β1 and ErbB3 induce EMT, cancer cell migration and invasion through the PI3k/Akt-phospho-Smad2-Snail signaling pathway in SK-BR-3 and MCF7 breast cancer cells.
Source: BMC Cancer - August 12, 2013 Category: Cancer & Oncology Authors: Jinkyoung KimHoiseon JeongYoungseok LeeChungyeul KimHankyeom KimAeree Kim Source Type: research

17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells
Conclusions: This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer.
Source: BMC Cancer - May 29, 2015 Category: Cancer & Oncology Authors: Anissa BelkaidSabrina DuguayRodney OuelletteMarc Surette Source Type: research

Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
Conclusion: In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these compounds have differential effects on cancer cells in culture. Garcinol treatment alters expression of chromatin modifying enzymes in MCF7 cells, resulting in reprogramming of key histone and p53 PTMs and growth arrest, underscoring its potential as a cancer chemopreventive agent.
Source: BMC Cancer - January 29, 2013 Category: Cancer & Oncology Authors: Hilary CollinsMagdy AbdelghanyMarie MessmerBaigong YueSian DeevesKarin KindleKempegowda MantelinguAkhmed AslamG WinklerTapas KunduDavid Heery Source Type: research

Expressional alterations in functional ultra-conserved non-coding RNAs in response to all-trans retinoic acid - induced differentiation in neuroblastoma cells
Conclusions: Our results indicate that significant numbers of T-UCRs have altered expression levels in response to ATRA. While the precise roles that T-UCRs might play in cancer or in normal development are largely unknown and an important area for future study, our findings strongly indicate that the function of non-coding RNA T-UC.300A is connected with proliferation, invasion and the inhibition of differentiation of neuroblastoma cell lines prior to ATRA treatment.
Source: BMC Cancer - April 8, 2013 Category: Cancer & Oncology Authors: Karen WattersKenneth BryanNiamh FoleyMaria MeehanRaymond Stallings Source Type: research

High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
Conclusions: Our results suggest that Wee1 may be involved in the progression of vulvar carcinomas. Based on our in vitro results, Wee1 is unlikely to function as a target for mono-treatment of these patients.
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Gry MagnussenEllen HellesyltJahn NeslandClaes TropeVivi FlørenesRuth Holm Source Type: research

Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases
Conclusion: PEI-mediated delivery of sticky siRNAs targeting genes involved in tumor progression such as survivin and cyclin B1, either alone or in combination with chemotherapeutic drugs, represents a promising strategy for melanoma treatment.
Source: BMC Cancer - July 9, 2013 Category: Cancer & Oncology Authors: Valerie KedingerAline MeulleOmar ZounibMarie-Elise BonnetJean-Baptiste GossartElodie BenoitMelanie MessmerPattabhiraman ShankaranarayananJean-Paul BehrPatrick ErbacherAnne-Laure Bolcato-Bellemin Source Type: research

HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis
Conclusion: the present study confirms the overexpression of HOXB7 mRNA expression in PDAC and demonstrates that decreasing its protein level by siRNA could significantly increase apoptosis and modulate several biological processes. HOXB7 might be a promising target for future therapies.
Source: BMC Cancer - October 2, 2013 Category: Cancer & Oncology Authors: Thais ChileMaria FortesMaria Corrêa-GiannellaHelena BrentaniDurvanei AugustoRenato PugaVanessa de PaulaMarcia KubruslyEstela NovakTelésforo BacchellaRicardo Giorgi Source Type: research

High epiregulin expression in human U87 glioma cells relies on IRE1alpha and promotes autocrine growth through EGF receptor
Conclusion: EREG may contribute to glioma progression under the control of IRE1alpha, as exemplified here by the autocrine proliferation loop mediated in U87 cells by the growth factor through ErbB1.
Source: BMC Cancer - December 13, 2013 Category: Cancer & Oncology Authors: Gregor AufArnaud JabouilleMaylis DeluginSylvaine GuéritRaphael PineauSophie NorthNatalia PlatonovaMarlène MaitreAlexandre FavereauxPeter VajkoczyMasaharu SenoAndreas BikfalviDmitri MinchenkoOleksandr MinchenkoMichel Moenner Source Type: research