Expressional alterations in functional ultra-conserved non-coding RNAs in response to all-trans retinoic acid - induced differentiation in neuroblastoma cells

Conclusions:
Our results indicate that significant numbers of T-UCRs have altered expression levels in response to ATRA. While the precise roles that T-UCRs might play in cancer or in normal development are largely unknown and an important area for future study, our findings strongly indicate that the function of non-coding RNA T-UC.300A is connected with proliferation, invasion and the inhibition of differentiation of neuroblastoma cell lines prior to ATRA treatment.

Source: BMC Cancer - April 8, 2013 Category: Cancer & Oncology Authors: Karen WattersKenneth BryanNiamh FoleyMaria MeehanRaymond Stallings Source Type: research