Sox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity

Conclusion:
Sox2 regulates the invasiveness of BC cells via a mechanism that is dependent on Twist1 and the transcriptional status of Sox2. Our results have further highlighted a new level of biological complexity and heterogeneity of BC cells that may carry significant clinical implications.

Source: BMC Cancer - July 1, 2013 Category: Cancer & Oncology Authors: Fang WuXiaoxia YePeng WangKaren JungChengsheng WuDonna DouglasNorman KnetemanGilbert BigrasYupo MaRaymond Lai Source Type: research