Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

Conclusion:
In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these compounds have differential effects on cancer cells in culture. Garcinol treatment alters expression of chromatin modifying enzymes in MCF7 cells, resulting in reprogramming of key histone and p53 PTMs and growth arrest, underscoring its potential as a cancer chemopreventive agent.

Source: BMC Cancer - January 29, 2013 Category: Cancer & Oncology Authors: Hilary CollinsMagdy AbdelghanyMarie MessmerBaigong YueSian DeevesKarin KindleKempegowda MantelinguAkhmed AslamG WinklerTapas KunduDavid Heery Source Type: research