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Source: BMC Cancer

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Total 95 results found since Jan 2013.

High epiregulin expression in human U87 glioma cells relies on IRE1¿ and promotes autocrine growth through EGF receptor
Conclusion: EREG may contribute to glioma progression under the control of IRE1alpha, as exemplified here by the autocrine proliferation loop mediated in U87 cells by the growth factor through ErbB1.
Source: BMC Cancer - December 13, 2013 Category: Cancer & Oncology Authors: Gregor AufArnaud JabouilleMaylis DeluginSylvaine GuéritRaphael PineauSophie NorthNatalia PlatonovaMarlène MaitreAlexandre FavereauxPeter VajkoczyMasaharu SenoAndreas BikfalviDmitri MinchenkoOleksandr MinchenkoMichel Moenner Source Type: research

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
Background: Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. We studied the influence of histological subtype on protein expression with reverse phase protein array (RPPA) and assessed proteomic changes associated with ARID1A mutation/BAF250a expression in EC and CCC. Methods: Immunohistochemistry (IHC) for BAF250a expression was performed on 127 chemotherapy-naive ovarian carcinomas (33...
Source: BMC Cancer - February 22, 2014 Category: Cancer & Oncology Authors: Kimberly WiegandBryan HennessySamuel LeungYemin WangZhenlin JuMollianne McGahrenSteve KallogerSarah FinlaysonKatherine Stemke-HaleYiling LuFan ZhangMichael AnglesioBlake GilksGordon MillsDavid HuntsmanMark Carey Source Type: research

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells
Conclusion: Our overall results demonstrate that mPEPCK is a useful predictor of a response to chemoradiotherapy in patients with rectal cancer.
Source: BMC Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Ji-Won ParkSeung KimWon KimJun HongKyung-Hee KimHyun YeoJae LeeM KimJong KimSe YangDae KimJae OhJae ChoByong Yoo Source Type: research

Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype
Conclusions: E2F1 acts as a transcriptional activator for MMPs and directly enhances MMP transcription by binding to E2F1 binding sequences in the promoter, or indirectly activates MMPs through enhanced Sp1 and NF-kappa B as a consequence of E2F1 activation in SCLC.
Source: BMC Cancer - April 22, 2014 Category: Cancer & Oncology Authors: Zunling LiYanxia GuoHanming JiangTingguo ZhangChangzhu JinCharles YoungHuiqing Yuan Source Type: research

YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells
Conclusions: To conclude, in a subset of BC cells, namely RR cells, YB-1 regulates Sox2 to coordinately maintain stemness and tumorigenic properties.
Source: BMC Cancer - May 9, 2014 Category: Cancer & Oncology Authors: Karen JungFang WuPeng WangXiaoxia YeBassam AbdulkarimRaymond Lai Source Type: research

14-3-3sigma induces heat shock protein 70 expression in hepatocellular carcinoma
Conclusions: Our findings indicate that 14-3-3sigma participates in promoting HCC cell migration and tumor development via beta-catenin/HSF-1alpha/HSP70 pathway regulation. Thus, 14-3-3sigma alone or combined with HSP70 are potential prognostic biomarkers for HCC.
Source: BMC Cancer - June 12, 2014 Category: Cancer & Oncology Authors: Chia-Chia LiuYee-Jee JanBor-Sheng KoYao-Ming WuShu-Man LiangShyh-Chang ChenYen-Ming LeeTzu-An LiuTzu-Ching ChangJohn WangSong-Kun ShyueLi-Ying SungJun-Yang Liou Source Type: research

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling
Conclusion: Our results demonstrate that the impact of S6K1 kinase on neuroblastoma cells is not mediated through modulation of GLI1 expression/activity.
Source: BMC Cancer - August 18, 2014 Category: Cancer & Oncology Authors: Yumei DiaoMohammed RahmanVictoria VillegasMalin WickströmJohn JohnsenPeter Zaphiropoulos Source Type: research

Btbd7 contributes to reduced E-cadherin expression and predicts poor prognosis in non-small cell lung cancer
Conclusions: Btbd7 contributes to reduced expression of E-cadherin and may be a promising cancer marker in non-small cell lung cancer.
Source: BMC Cancer - September 24, 2014 Category: Cancer & Oncology Authors: Chuifeng FanYuan MiaoXiupeng ZhangDi LiuGuiyang JiangXuyong LinQiang HanLan LuanZhonghai XuEnhua Wang Source Type: research

The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype
Conclusions: Our results establish a link between aberrant P-cadherin expression and hypoxic, glycolytic and acid-resistant breast cancer cells, suggesting a possible role for this marker in cancer cell metabolism.
Source: BMC Cancer - October 1, 2014 Category: Cancer & Oncology Authors: Bárbara SousaAna RibeiroAna NobreNair LopesDiana MartinsCéline PinheiroAndré VieiraAndré AlbergariaRené GerhardFernando SchmittFátima BaltazarJoana Paredes Source Type: research

Inhibition of STAT3-interacting protein 1 (STATIP1) promotes STAT3 transcriptional up-regulation and imatinib mesylate resistance in the chronic myeloid leukemia
Conclusions: Our data suggest that STATIP1 may be a negative regulator of STAT3 and demonstrate its involvement in IM therapy resistance in CML.
Source: BMC Cancer - November 23, 2014 Category: Cancer & Oncology Authors: André MencalhaStephany CorrêaDaniela SallesBárbara Du RocherMarcelo SantiagoEliana Abdelhay Source Type: research

Fibulin-5 inhibits hepatocellular carcinoma cell migration and invasion by down-regulating matrix metalloproteinase-7 expression
Conclusions: These results indicate that Fibulin-5 may serve as a prognostic biomarker and inhibits HCC invasion and metastasis by suppressing MMP-7 expression.
Source: BMC Cancer - December 12, 2014 Category: Cancer & Oncology Authors: Kangsheng TuChangwei DouXin ZhengChao LiWei YangYingmin YaoQingguang Liu Source Type: research

Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein
Conclusions: Our results demonstrate existence of a functional loop involving Let-7a, STAT3 and miR-21 which were found potentially regulated by viral oncoprotein E6. Implications: miR-21 and Let-7a along with STAT3 may prove useful targets for pharmacological intervention for management of cervical cancer.
Source: BMC Cancer - December 23, 2014 Category: Cancer & Oncology Authors: Gauri ShishodiaGaurav VermaYogesh SrivastavaRavi MehrotraBhudev DasAlok Bharti Source Type: research

The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells
Conclusions: These results reveal that EphB4 regulates integrin β8 expression and that integrin β8 plays a hitherto unrecognized role in the motility of prostate cancer cells and thus targeting integrin β8 may be a new treatment strategy for prostate cancer.
Source: BMC Cancer - March 22, 2015 Category: Cancer & Oncology Authors: Inga Mertens-WalkerBruno FernandiniMohanan MaharajAnja RockstrohColleen NelsonAdrian HeringtonSally-Anne Stephenson Source Type: research

Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation
Conclusions: Our data indicate that i) functional Cx43 is required for mural cell-induced endothelial quiescence, and ii) downregulation of Cx43 GJ by tumors frees endothelium to respond to angiogenic cues. These data define a novel and important role for maintained Cx43 function in regulation of vessel quiescence, and suggest its loss may contribute to pathological tumor angiogenesis.
Source: BMC Cancer - May 23, 2015 Category: Cancer & Oncology Authors: Mayur ChoudharyChristine NaczkiWenhong ChenKeith BarlowL. CaseLinda Metheny-Barlow Source Type: research

Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival
Conclusion: We have shown that combined ↑cancer and ↑stromal cell CXCL16 expression is an independent positive prognostic factor in NSCLC. Further studies are warranted to elucidate the biological mechanism underlying this finding.
Source: BMC Cancer - May 29, 2015 Category: Cancer & Oncology Authors: Sigurd HaldYury KiselevSamer Al-SaadElin RichardsenCharles JohannessenMarte EilertsenThomas KilvaerKhalid Al-ShibliSigve AndersenLill-Tove BusundRoy BremnesTom Donnem Source Type: research