Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein

Conclusions:
Our results demonstrate existence of a functional loop involving Let-7a, STAT3 and miR-21 which were found potentially regulated by viral oncoprotein E6. Implications: miR-21 and Let-7a along with STAT3 may prove useful targets for pharmacological intervention for management of cervical cancer.

Source: BMC Cancer - December 23, 2014 Category: Cancer & Oncology Authors: Gauri ShishodiaGaurav VermaYogesh SrivastavaRavi MehrotraBhudev DasAlok Bharti Source Type: research