Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation

Conclusions:
Our data indicate that i) functional Cx43 is required for mural cell-induced endothelial quiescence, and ii) downregulation of Cx43 GJ by tumors frees endothelium to respond to angiogenic cues. These data define a novel and important role for maintained Cx43 function in regulation of vessel quiescence, and suggest its loss may contribute to pathological tumor angiogenesis.

Source: BMC Cancer - May 23, 2015 Category: Cancer & Oncology Authors: Mayur ChoudharyChristine NaczkiWenhong ChenKeith BarlowL. CaseLinda Metheny-Barlow Source Type: research