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AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas
Conclusions: Our results suggest that AXL signaling contributes to the aggressiveness of DDLPS and PLS, and that AXL is therefore a potential therapeutic target for treatment of these rare, yet devastating tumors.
Source: BMC Cancer - November 14, 2015 Category: Cancer & Oncology Authors: Caitlin MayJeannine GarnettXiaoYan MaSharon LandersDavis IngramElizabeth DemiccoGhadah Al SannaaTona VuLixia HanYi ZhangChristine KivlinSvetlana BolshakovAzad KalamJuehui LiuFuguo ZhouDominique BroccoliWei-Lien WangAlexander LazarRaphael PollockDina LevKe Source Type: research

Transarterial chemoembolization of hepatocellular carcinoma in a rat model: the effect of additional injection of survivin siRNA to the treatment protocol
Transarterial chemoembolization is one of the most widely accepted interventional treatment options for treatment of hepatocellular carcinoma. Still there is a lack of a standard protocol regarding the injecte...
Source: BMC Cancer - May 23, 2016 Category: Cancer & Oncology Authors: Thomas J. Vogl, Elsie Oppermann, Jun Qian, Ulli Imlau, Andreas Tran, Yousef Hamidavi, Huedayi Korkusuz, Wolf Otto Bechstein, Nour-Eldin Abdel-Rehim Nour-Eldin, Tatjana Gruber-Rouh, Renate Hammerstingl and Nagy Naguib Naeem Naguib Source Type: research

Methodological study to evaluate the psychometric properties of FACIT-CD in a sample of Brazilian women with cervical intraepithelial neoplasia
The occurrence of cervical intraepithelial neoplasia (CIN) is associated with changes in health-related quality of life, including psychological factors, such as fear and shame, and changes in sexuality and se...
Source: BMC Cancer - October 16, 2017 Category: Cancer & Oncology Authors: Cristiane Menezes Sirna Fregnani, Jos é Humberto Tavares Guerreiro Fregnani and Adhemar Longatto-Filho Tags: Research article Source Type: research

Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells
This study investigated the effects of SALL2 on human ovarian carcinoma (OC) A2780 cells and the probable mechanism.
Source: BMC Cancer - December 11, 2017 Category: Cancer & Oncology Authors: Fang Miao, Xueshan Zhang, Yanning Cao, Yue Wang and Xiaoshu Zhang Tags: Research article Source Type: research

Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence
The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular ...
Source: BMC Cancer - July 6, 2020 Category: Cancer & Oncology Authors: Jennifer L. S. Willoughby, Kelly George, Mark P. Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E. Schaus, Kevin Fitzgerald, Jagesh Shah and Ulla Hansen Tags: Research article Source Type: research

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