Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases

Conclusion:
PEI-mediated delivery of sticky siRNAs targeting genes involved in tumor progression such as survivin and cyclin B1, either alone or in combination with chemotherapeutic drugs, represents a promising strategy for melanoma treatment.

Source: BMC Cancer - July 9, 2013 Category: Cancer & Oncology Authors: Valerie KedingerAline MeulleOmar ZounibMarie-Elise BonnetJean-Baptiste GossartElodie BenoitMelanie MessmerPattabhiraman ShankaranarayananJean-Paul BehrPatrick ErbacherAnne-Laure Bolcato-Bellemin Source Type: research