HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis

Conclusion:
the present study confirms the overexpression of HOXB7 mRNA expression in PDAC and demonstrates that decreasing its protein level by siRNA could significantly increase apoptosis and modulate several biological processes. HOXB7 might be a promising target for future therapies.

Source: BMC Cancer - October 2, 2013 Category: Cancer & Oncology Authors: Thais ChileMaria FortesMaria Corrêa-GiannellaHelena BrentaniDurvanei AugustoRenato PugaVanessa de PaulaMarcia KubruslyEstela NovakTelésforo BacchellaRicardo Giorgi Source Type: research