microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18

Conclusions: We demonstrated that miR-30b/c was down-regulated in NSCLC specimens compared with adjacent non-tumor tissues. miR-30b/c directly targeted and down-regulated Rab18 expression and inhibited NSCLC cells proliferation. These data indicated that miR-30b/c could serve as a tumor suppressor gene involved in NSCLC pathogenesis.

http://www.biomedcentral.com/1471-2407/14/703

Source: BMC Cancer - September 24, 2014 Category: Cancer & Oncology Authors: Keng ZhongKun ChenLin HanBailing Li Source Type: research