Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer

Conclusions:
The present study shows that elevated EET levels in BC tissues are associated with upregulation of CYP2C8, 2C9, and 2J2, and downregulation of sEH, and are also associated with aggressive cell behavior in BC patients.

Source: BMC Cancer - November 18, 2014 Category: Cancer & Oncology Authors: Xiaolong WeiDonghong ZhangXiaowei DouNa NiuWenhe HuangJingwen BaiGuo-Jun Zhang Source Type: research