CUB Domain Containing Protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells

Conclusions: A number of recent studies have assigned a potentially important role for the cell-surface protein CDCP1 in invasion and metastasis of a several types of human cancer cells. In this study, CDCP1 was shown to modulate cell-substratum adhesion and motility in colon cancer cell lines, with some variation depending on the colon cancer cell type. CDCP1 and CD9 were co-expressed at the mRNA and protein level and we obtained evidence for the presence of a molecular complex of these proteins in SW480 colon cancer cells.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Source Type: research