Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation
Conclusions:
We demonstrate a cross-talk between alpha1D-AR and TRPV1, that is involved in the control of PC3 cell proliferation. These data strongly support for a putative novel pharmacological approach in the treatment of PCa by targeting both alpha1D-AR and TRPV1 channels.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Maria MorelliConsuelo AmantiniMassimo NabissiSonia LiberatiClaudio CardinaliValerio FarfarielloDaniele TomassoniWilma QuagliaAlessandro PiergentiliAlessandro BonifaziFabio Del BelloMatteo SantoniGabriele MammanaLucilla ServiAlessandra FilosaAngela Gismond Source Type: research