P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement

Conclusion:
P-gp over-expression is a possible mechanism of acquired resistance to 17-DMAG in cells with ALK rearrangement.

Source: BMC Cancer - July 29, 2015 Category: Cancer & Oncology Authors: Hee KimKye LeeYoung KimYun ChoiJung-Eun LeeChang ChoiIn-Jeoung BaekJin RhoJae Lee Source Type: research