Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma

Conclusions:
Together, these data highlight a broader role for dysregulated MAPK7 in driving tumorigenesis within niche populations of highly prevalent tumor types, and describe current efforts in establishing a robust drug discovery screening cascade.

Source: BMC Cancer - June 4, 2015 Category: Cancer & Oncology Authors: Paul GavineMei WangDehua YuEva HuChunlei HuangJenny XiaXinying SuJoan FanTianwei ZhangQingqing YeLi ZhengGuanshan ZhuZiliang QianQingquan LuoYing HouQunsheng Ji Source Type: research