Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways
Conclusions:
TK1 was responsible for anticancer activity of dT-QX while levels of TYMP counteracted such an activity. The counteraction by TYMP could be overcome with RNA silencing to significantly enhance the dT-QX selectivity in cancer cells.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Qiong WeiHaijuan LiuHonghao ZhouDejun ZhangZhiwei ZhangQibing Zhou Source Type: research