Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways

Conclusions: TK1 was responsible for anticancer activity of dT-QX while levels of TYMP counteracted such an activity. The counteraction by TYMP could be overcome with RNA silencing to significantly enhance the dT-QX selectivity in cancer cells.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Source Type: research