Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13
Conclusions:
We show that the PKA-anchoring protein AKAP13 is essential for the phosphorylation of ERαS305, which leads to tamoxifen resistance both in cell lines and tamoxifen-treated breast cancer patients.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Cristiane Bentin ToaldoXanthippi AlexiKarin BeelenMarleen KokMichael HauptmannMaurice JansenEls BernsJacques NeefjesSabine LinnRob MichalidesWilbert Zwart Source Type: research