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Total 48 results found since Jan 2013.

GE Healthcare Life Sciences Educational Webinar Presents Getting...
The Webinar on November 13, 2014 will focus on working with siRNA, experimental considerations, and analysis best practices(PRWeb November 11, 2014)Read the full story at http://www.prweb.com/releases/2014/11/prweb12316742.htm
Source: PRWeb: Medical Pharmaceuticals - November 11, 2014 Category: Pharmaceuticals Source Type: news

The AMPK-TSC1/2-mTOR signaling pathway regulates cigarette smoking-induced inflammation and apoptosis in airway epithelial cells
Conclusion: mTOR signaling pathway plays an important role in CS–induced airway inflammation and apoptosis, eventually participating in COPD.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Liu, J., Li, W., Ying, S., Shen, H., Chen, Z. Tags: 6.3 Tobacco, Smoking Control and Health Education Source Type: research

Insulin response dysregulation explains abnormal fat storage and increased risk of diabetes mellitus type 2 in Cohen Syndrome
This study, in association with the in-depth analysis of the metabolic status of the patients, thus allowed us to recommend appropriate nutritional education to prevent the occurrence of diabetes mellitus and to put forward recommendations for the follow-up of CS patients, in particular with regard to the development of metabolic syndrome. We also suggest replacing the term obesity by abnormal fat distribution in CS, which should reduce the number of inappropriate diagnoses in patients who are referred only on the basis of intellectual deficiency associated with obesity.
Source: Human Molecular Genetics - November 5, 2015 Category: Genetics & Stem Cells Authors: Limoge, F., Faivre, L., Gautier, T., Petit, J.-M., Gautier, E., Masson, D., Jego, G., El Chehadeh-Djebbar, S., Marle, N., Carmignac, V., Deckert, V., Brindisi, M.-C., Edery, P., Ghoumid, J., Blair, E., Lagrost, L., Thauvin-Robinet, C., Duplomb, L. Tags: ARTICLES Source Type: research

Risk management of onco-hematological drugs: how and how fast can we improve?
CONCLUSIONS: Our analysis of the Ministerial Raccomandazione 14 urges implementation of the resources for ensuring quality and safety during prescription, preparation, and administration of anticancer drugs. PMID: 27581596 [PubMed - as supplied by publisher]
Source: Tumori - September 2, 2016 Category: Cancer & Oncology Tags: Tumori Source Type: research

Fucoidan reduced the invasion of oral squamous cell carcinoma cells and modified their effects to macrophages
In this study, we analyzed the effects of fucoidan on invasion of OSCC cells, and their regulation to macrophages, trying to evaluate its role as a potential therapy for OSCC. CAL27 and THP-1-derived macrophages were used as models for OSCC cells and tumor-infiltrated macrophages in the in vitro study, respectively. The effects of fucoidan on invasion of OSCC cells and their recruitment to macrophages were analyzed by transwell assay. KIF4A siRNA transfection was performed to investigate its role in fucoidan-modulated OSCC cells invasion. CCL3-neutralizing antibody was added into the conditioned medium of OSCC cells to eva...
Source: Medical Oncology - December 20, 2016 Category: Cancer & Oncology Source Type: research

Thick melanoma in Tuscany.
CONCLUSIONS: If we want to obtain better results on diagnosis of skin melanoma we have to think a new strategy. At least to think over the educational messages discriminating people more at risk of incidence of melanoma from people more at risk to die from melanoma, and to renewed active involvement of the Gen- eral Practitioners . PMID: 28290624 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - March 17, 2017 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

LSC - 2017 - Re-education of tumor-associated macrophages by modulating histone deacetylases in lung cancer
Conclusions: Suppression of HDAC2 switches M2-like TAMs into M1-like phenotype and regulates tumor cell functions. Modulation of HDAC2 may provide a novel strategy for TAMs repolarization and cancer therapy.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Zheng, X. Tags: Lung Cancer Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

FGF21 as Modulator of Metabolism in Health and Disease
In conclusion, FGF21 belongs to a promising class of cytokines that are induced in response to stress and that can be used as a drug, drug target, or through a biomarker, depending on the physio-pathological context. All these findings will become clear when FGF21 will be used as a therapeutic molecule, exploiting the beneficial effects of FGF21 for treating metabolic disease or when it will be blocked to ameliorate disease progression and the onset of disease. Author Contributions CT and MS wrote the manuscript. VR contributed to the discussion. Funding This work was supported from the AFM-Telethon (19524), Italian Mi...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic ...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Engineered Extracellular Vesicles From Human Periodontal-Ligament Stem Cells Increase VEGF/VEGFR2 Expression During Bone Regeneration
Conclusion In conclusion our results evidenced that 3D-COL/hPDLSCs/PEI-EVs may be an efficacious strategy to induce bone regeneration and vascularization of bone defects, thanks to its capacity to increase the levels of VEGF. Ethics Statement The study was performed in accordance with the guidelines of the Helsinki Declaration (2013). The written approval for the human periodontal ligament collection performed in this study has been obtained from the Medical Ethics Committee at the Medical School, “G. d’Annunzio” University of Chieti–Pescara, Chieti, Italy (n°266/17.04.14, Principal in...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

FKN Facilitates HK-2 Cell EMT and Tubulointerstitial Lesions via the Wnt/ β-Catenin Pathway in a Murine Model of Lupus Nephritis
In this study, we therefore examined whether FKN could stimulate the process of EMT, NF-kB, TGFβ, CCL22, F4/80, inflammation, and tubulointerstitial fibrosis in a murine model of LN. We also determined whether FKN was involved in the EMT process of Wnt/β-catenin-expressing HK-2 cells. Mechanistically, we ascertained, for the first time, whether FKN up-regulated EMT-related gene signatures (e.g., vimentin, α-SMA), and hence, renal tubulointerstitial fibrogenesis, and the role of the Wnt/β-catenin signaling pathway in this process. Materials and Methods Cell Culture, Stable Infection, and Gr...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Study identifies therapeutic target for high blood pressure in the lungs
This study was supported by grants from the National Institutes of Health and the American Heart Association; and by the Foundation for Anesthesia Education and Research.
Source: UCLA Newsroom: Health Sciences - October 1, 2019 Category: Universities & Medical Training Source Type: news

88PTranscription factors of snail family in the regulation of resistance of breast cancer cells to hypoxic conditions
ConclusionsModulation of Snail-associated signaling pathways is a perspective target for increase of cancer cell tolerance to chronic hypoxia, and inhibition of metastatic process in breast cancer cells.Legal entity responsible for the studyThe authors.FundingGrant no. 14.W03.31.0020 between the Ministry of Science and Education of the Russian Federation and Institute of Gene Biology, Russian Academy of Sciences.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer.
Abstract Extracellular vesicles (EVs) are key players of intercellular communication in physiological and pathological conditions. In cancer, EVs mediate complex signaling mechanisms between cancer cells and the tumor microenvironment, and can influence tumor progression and the response to existing therapies. Importantly, EVs can be loaded with therapeutic agents and modified to display tumor-targeting molecules. In the field of nanomedicine, EVs have been engineered to serve as therapeutic delivery vehicles for several anti-cancer agents, including antibodies, chemotherapy, compounds, CRISPR/Cas9 and siRNA. Nota...
Source: Endocrinology - January 7, 2021 Category: Endocrinology Authors: Kugeratski FG, McAndrews KM, Kalluri R Tags: Endocrinology Source Type: research