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Drug: Tamoxifen

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Total 112 results found since Jan 2013.

High IKK α expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)‐positive breast cancer
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - December 21, 2016 Category: Cancer & Oncology Authors: Lindsay Bennett, Jean Quinn, Pamela McCall, Elizabeth A Mallon, Paul G Horgan, Donald C McMillan, Andrew Paul, Joanne Edwards Tags: Research Article Source Type: research

GSE90531 Deletion of Histone Deacetylase 3 in Adult Beta Cells Improves Glucose Tolerance via Increased Insulin Secretion
Conclusions: HDAC3 plays an i mportant role in regulating insulin secretion in vivo and therapeutic intervention may improve glucose homeostasis.
Source: GEO: Gene Expression Omnibus - November 26, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

Deletion of Histone Deacetylase 3 in Adult Beta Cells Improves Glucose Tolerance via Increased Insulin Secretion
Conclusions HDAC3 plays an important role in regulating insulin secretion in vivo and therapeutic intervention may improve glucose homeostasis.
Source: Molecular Metabolism - November 22, 2016 Category: Endocrinology Source Type: research

A role for the accessory type III transforming growth factor {beta} receptor (Tgfbr3) in lung alveolarisation
Bronchopulmonary dysplasia (BPD) is a common complication of premature birth, characterised by arrested secondary septation. Molecular mechanisms of arrested secondary septation are not known. Members of the transforming growth factor (TGF)-β growth factor superfamily are accredited with key roles in lung development and BPD. We profiled lung expression of the TGF-β signaling machinery in mice in a hyperoxia-based BPD model, and detected a down-regulation Tgfbr3 expression. Using laser-capture microdissection, Tgfbr3 mRNA expression was reduced in both the lung vascular and parenchymal compartments in response to...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Pozarska, A., Niess, G., Seeger, W., Morty, R. Tags: 3.3 Mechanisms of Lung Injury and Repair Source Type: research

Estrogenic compound attenuates angiotensin II-induced vascular smooth muscle cell proliferation through interaction between LKB1 and estrogen receptor α
Publication date: Available online 9 September 2016 Source:Journal of Pharmacological Sciences Author(s): Sun Ae Kim, Kyung Young Lee, Jae-Ryong Kim, Hyoung Chul Choi The prevalence rate of cardiovascular disease is higher for males than females, and estradiol (E2) induces AMP-activated protein kinase (AMPK) activation, which is known to regulate proliferation of VSMC. We identified the estrogenic properties of nordihydrogaiaretic acid (NDGA, a lignan phytoestrogen) that inhibit VSMC proliferation and explored the underlying mechanisms. Both the phosphorylation and expression of LKB1 were increased by NDGA. In addition, N...
Source: Journal of Pharmacological Sciences - September 8, 2016 Category: Drugs & Pharmacology Source Type: research

Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer.
Authors: Joshi T, Elias D, Stenvang J, Alves CL, Teng F, Lyng MB, Lykkesfeldt AE, Brünner N, Wang J, Gupta R, Workman CT, Ditzel HJ Abstract Tamoxifen is an effective anti-estrogen treatment for patients with estrogen receptor-positive (ER+) breast cancer, however, tamoxifen resistance is frequently observed. To elucidate the underlying molecular mechanisms of tamoxifen resistance, we performed a systematic analysis of miRNA-mediated gene regulation in three clinically-relevant tamoxifen-resistant breast cancer cell lines (TamRs) compared to their parental tamoxifen-sensitive cell line. Alterations in the expressi...
Source: Oncotarget - August 18, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments through an Increment in ROS Production
In conclusion, SIRT3 could be a therapeutic target for breast cancer, improving the effectiveness of CDDP and TAM treatments. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - July 16, 2016 Category: Biochemistry Authors: Margalida Torrens‐Mas, Daniel Gabriel Pons, Jorge Sastre‐Serra, Jordi Oliver, Pilar Roca Tags: Article Source Type: research

Tamoxifen-induced cytotoxicity in breast cancer cells is mediated by glucose-regulated protein 78 (GRP78) via AKT (Thr308) regulation.
Abstract Glucose regulated protein 78 (GRP78) has recently been suggested to be associated with drug resistance in breast cancer patients. However, the precise role of GRP78 in drug resistance and the involved signaling pathways are not clearly understood. In the present study, we show that among a panel of drugs, namely Paclitaxel (TAX), Doxorubicin (DOX), 5-fluorouracil (5-FU), UCN-01 and Tamoxifen (TAM) used, TAM alone up-regulated the expression of GRP78 significantly and induced apoptosis in MCF-7 and MDA-MB-231 cells. Interestingly, inhibition of GRP78 by a specific pharmacological inhibitor, VER-155008 augm...
Source: The International Journal of Biochemistry and Cell Biology - May 31, 2016 Category: Biochemistry Authors: Pujari R, Jose J, Bhavnani V, Kumar N, Shastry P, Pal JK Tags: Int J Biochem Cell Biol Source Type: research

San Huang Decoction downregulates Aurora kinase A to inhibit breast cancer cell growth and enhance chemosenstivity to anti-tumor drugs
Publication date: Available online 18 May 2016 Source:Pathology - Research and Practice Author(s): Yanlei Xu, Xu Chen, Xiyan Chen, Weihe Bian, Chang Yao, Xiaoqing Zhang, Xiaoshu Zhu, Jiajing Chen, Xiaozhou Ye Our study aimed to explore whether San Huang Decoction (SHD) inhibited the development of breast cancer by regulating Aurora A. Human breast cancer cell lines MCF-7 and MDA-MB-231 were cultured and SHD extract was prepared. Cell growth assay and apoptosis analysis were respectively performed to detect the effects of SHD on breast cancer cells. In addition, the effects of SHD on the expression of Aurora A an...
Source: Pathology Research and Practice - May 17, 2016 Category: Pathology Source Type: research

Oxidative stress and glyoxalase I activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative
Conclusions Dicarbonyl toxicity was mediated by oxidative stress and GLO1 activity determines aldehyde toxicity in tamoxifen resistant cells. General Significance Glyoxalases might be predictive biomarkers for tamoxifen resistance and a putative target for the treatment of tamoxifen resistant breast cancer patients. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) General Subjects - March 22, 2016 Category: Biochemistry Source Type: research

Oxidative stress and glyoxalase-1 activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen-resistant derivative
Conclusions Dicarbonyl toxicity was mediated by oxidative stress and GLO-1 activity determines aldehyde toxicity in tamoxifen resistant cells. General Significance. Glyoxalases might be predictive biomarkers for tamoxifen resistance and a putative target for the treatment of tamoxifen resistant breast cancer patients. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) General Subjects - March 12, 2016 Category: Biochemistry Source Type: research

Oxidative stress and glyoxalase-1 activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative.
CONCLUSIONS: Dicarbonyl toxicity was mediated by oxidative stress and GLO-1 activity determines aldehyde toxicity in tamoxifen resistant cells. GENERAL SIGNIFICANCE: Glyoxalases might be predictive biomarkers for tamoxifen resistance and a putative target for the treatment of tamoxifen resistant breast cancer patients. PMID: 26971627 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 10, 2016 Category: Biochemistry Authors: Nass N, Sel S, Ignatov A, Roessner A, Kalinski T Tags: Biochim Biophys Acta Source Type: research

Abstract P1-05-06: Essential role of notch-4/STAT3 signaling in epithelial-mesenchymal transition of tamoxifen-resistant human breast cancer
In conclusion, inhibition of Notch signaling may have efficacy in the treatment of breast cancer metastasis.Citation Format: Bui QT, Kang KW. Essential role of notch-4/STAT3 signaling in epithelial-mesenchymal transition of tamoxifen-resistant human breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-05-06.
Source: Cancer Research - February 18, 2016 Category: Cancer & Oncology Authors: Bui, Q., Kang, K. Tags: Poster Session Abstracts Source Type: research

Over-expression of miR-451a can enhance the sensitivity of breast cancer cells to tamoxifen by regulating 14-3-3ζ, estrogen receptor α, and autophagy
Publication date: Available online 17 February 2016 Source:Life Sciences Author(s): Zhen-Ru Liu, Yi Song, Li-Hong Wan, Yuan-Yuan Zhang, Li-Mimg Zhou Aim To investigate the effects and mechanisms of miR-451a in the tamoxifen (TAM) resistance of breast cancer cells. Materials and methods TAM sensitive cells (MCF-7) and resistant cells (LCC2) were employed in the study. The lentivirus vectors of Lv-miR-451a, Lv-miR-451a sponge, and Lv-miR-451a NC were employed to increase or decrease the expression of miR-451a, respectively. SiRNA to 14-3-3ζ was used to inhibit expression of 14-3-3ζ. MTT assay was utilized to detect...
Source: Life Sciences - February 18, 2016 Category: Biology Source Type: research

Abstract S4-05: Interrogating the landscape of long noncoding RNAs in breast cancer to identify predictors of tamoxifen resistance
Conclusion: In this study, we develop the largest reported compendia of breast cancer lncRNAs. We prioritize BRCAT431 as the top lncRNA upregulated in ER-positive breast cancers, and demonstrate that it confers aggressive oncogenic phenotypes in vitro and in vivo. We identify a novel mechanism by which this lncRNA functions. Our results suggest that by promoting tamoxifen resistance, BRCAT431 increases the clinical risk of recurrence and metastases in breast cancer. Overall, this study supports the rationale for investigating lncRNAs as novel biomarkers and therapeutic targets in breast cancer.Citation Format: Feng FY, Nik...
Source: Cancer Research - February 18, 2016 Category: Cancer & Oncology Authors: Feng, F., Niknafs, Y., Han, S., Ma, T., Speers, C., Malik, R., Evans, J., Zhang, C., Pierce, L., Hayes, D., Rae, J., Chinnaiyan, A. Tags: General Session Abstracts Source Type: research