Oxidative stress and glyoxalase-1 activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen-resistant derivative

Conclusions Dicarbonyl toxicity was mediated by oxidative stress and GLO-1 activity determines aldehyde toxicity in tamoxifen resistant cells. General Significance. Glyoxalases might be predictive biomarkers for tamoxifen resistance and a putative target for the treatment of tamoxifen resistant breast cancer patients. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research