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Drug: Tamoxifen

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Total 112 results found since Jan 2013.

Knockdown of YAP/TAZ sensitizes tamoxifen-resistant MCF7 breast cancer cells
In conclusion, targeting the YAP/TAZ-PSAT1 axis could sensitize tamoxifen-resistant MCF7 breast cancer cells by modulating the mTORC1-survivin axis.PMID:35231654 | DOI:10.1016/j.bbrc.2022.02.083
Source: Biochemical and Biophysical Research communications - March 1, 2022 Category: Biochemistry Authors: Yu Jin Kim Se-Kyeong Jang Sung-Eun Hong Chan Sub Park Min-Ki Seong Hyun-Ah Kim Ki Soo Park Chun-Ho Kim In-Chul Park Hyeon-Ok Jin Source Type: research

Romidepsin and tamoxifen cooperatively induce senescence of pancreatic cancer cells through downregulation of FOXM1 expression and induction of reactive oxygen species/lipid peroxidation
CONCLUSION: Since FOXM1 is used as a prognostic marker and therapeutic target for pancreatic cancer, a combination of the clinically available drugs romidepsin and tamoxifen might be considered for the treatment of patients with pancreatic cancer.PMID:35099714 | DOI:10.1007/s11033-022-07192-9
Source: Molecular Biology Reports - January 31, 2022 Category: Molecular Biology Authors: Noriko Okuni Yoshio Honma Takeshi Urano Kenji Tamura Source Type: research

Targeting CDK7 reverses tamoxifen resistance through regulating stemness in ER+ breast cancer
CONCLUSION: Our data indicate, for the first time, that CDK7-targeted therapy in ER+ breast cancer ameliorates tamoxifen resistance, at least in part, by inhibiting cancer stemness. Thus, targeting CDK7 might represent a potential approach for relieving tamoxifen resistance in ER+ breast cancer.PMID:35000145 | DOI:10.1007/s43440-021-00346-9
Source: Pharmacological Reports - January 9, 2022 Category: Drugs & Pharmacology Authors: Yasmin M Attia Salama A Salama Samia A Shouman Cristina Ivan Abdelrahman M Elsayed Paola Amero Cristian Rodriguez-Aguayo Gabriel Lopez-Berestein Source Type: research

17 β-Estradiol activates Cl < sup > - < /sup > channels via the estrogen receptor α pathway in human thyroid cells
In this study, the effects of estrogen on chloride channel activities in human thyroid Nthy-ori3-1 cells were therefore investigated using the whole cell patch-clamp technique. The results showed that the extracellular application of 17β-estradiol (E2) activated Cl- currents, which reversed at a potential close to Cl- equilibrium potential and showed remarkable outward rectification and an anion permeability of I- > Br- > Cl- > gluconate. The Cl- currents were inhibited by the chloride channel blockers, NPPB and tamoxifen. Quantitative Real-time PCR results demonstrated that ClC-3 expression was highest in ClC fa...
Source: Channels - August 20, 2021 Category: Molecular Biology Authors: Meisheng Yu Yuan Wei Yanfang Zheng Lili Yang Long Meng Jiawei Lin Peisheng Xu Sanaa Ahmed Nagi Abdu Mahdy Linyan Zhu Shuang Peng Lixin Chen Liwei Wang Source Type: research

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling
Conclusions/interpretationIn summary, our study identifies HAND2 as a novel obesity-linked adipocyte transcription factor, highlighting new mechanisms of GR-dependent adipogenesis in humans and mice.Data availabilityArray data have been submitted to the GEO database at NCBI (GSE148699).Graphical abstract
Source: Diabetologia - August 1, 2021 Category: Endocrinology Source Type: research

Overexpression of TMEM47 Induces Tamoxifen Resistance in Human Breast Cancer Cells
CONCLUSIONS: Our results suggest that overexpression of TMEM47 in MCF-7 cells acquired TAM resistance to those cells, and knockdown of TMEM47 in TAMR/MCF-7 cells reversed their resistance to TAM. TMEM47 might confer TAM resistance on MCF-7 cells through the inhibition of apoptosis.PMID:33745390 | DOI:10.1177/15330338211004916
Source: Technology in Cancer Research and Treatment - March 22, 2021 Category: Cancer & Oncology Authors: Xin Men Mengyang Su Jun Ma Yueyang Mou Penggao Dai Chao Chen Xi An Cheng Source Type: research

PELP-1 regulates adverse responses to endocrine therapy in Estrogen Receptor (ER) positive breast cancer.
CONCLUSIONS: Our data confirms previous reports that anti-estrogens induce an adverse cell phenotype in ER+ breast cancer, particularly in the absence of homotypic cell contact. These results implicate E-cadherin and PELP-1 as potential biomarkers when deciding upon optimum adjuvant endocrine therapy, whereby tumours with high PELP-1/low E-cadherin expression may benefit from estrogen withdrawal therapy via aromatase inhibition, as opposed to ER modulation/antagonism. PMID: 33473257 [PubMed]
Source: Oncotarget - January 23, 2021 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes.
Abstract The pathological involvement of anion channels in vascular dysfunction that occurs during type 2 diabetes (T2D) is unclear. Here, we tested the hypothesis that TMEM16A, a calcium (Ca2+)-activated chloride (Cl-) channel, contributes to modifications in arterial contractility during T2D. Our data indicate that T2D increased TMEM16A mRNA in arterial smooth muscle cells (myocytes) and total and surface TMEM16A protein in resistance-size arteries of mice. To examine vascular cell types in which TMEM16A expression is upregulated, we generated a tamoxifen-inducible, smooth muscle-specific TMEM16A knockout (TMEM1...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 15, 2021 Category: Physiology Authors: Leo MD, Peixoto-Neves D, Yin W, Raghavan S, Muralidharan P, Mata-Daboin A, Jaggar JH Tags: Am J Physiol Heart Circ Physiol Source Type: research