Filtered By:
Drug: Tetracycline

This page shows you your search results in order of date.

Order by Relevance | Date

Total 16 results found since Jan 2013.

Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin
ConclusionOur work unravels a novel driver of photosensitivity in SLE: overactive Hippo signaling in SLE keratinocytes restricts YAP transcriptional activity, leading to shifts that promote UVB apoptosis.
Source: Arthritis and Rheumatology - April 19, 2023 Category: Rheumatology Authors: Grace A. Hile, Patrick Coit, Bin Xu, Amanda M. Victory, Mehrnaz Gharaee ‐Kermani, Shannon N. Estadt, Mitra P. Maz, Jacob W. S. Martens, Rachael Wasikowski, Craig Dobry, Lam C. Tsoi, Ramiro Iglesias‐Bartolome, Celine C. Berthier, Allison C Tags: Full Length Source Type: research

MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites RESEARCH
The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Because super-enhancers are frequently dysregulated in cancer, we hypothesized that MYC preferentially invades into super-enhancers and alters the cancer genome organization. To that end, we performed ChIP-seq, RNA-seq, circular chromosome conformation capture (4C-seq), and Spike-in Quantitative Hi-C (SIQHiC) on the U2OS osteosarcoma ce...
Source: Genome Research - April 8, 2022 Category: Genetics & Stem Cells Authors: See, Y. X., Chen, K., Fullwood, M. J. Tags: RESEARCH Source Type: research

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites RESEARCH
The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Since superenhancers are frequently dysregulated in cancer, we hypothesized that MYC preferentially invades into superenhancers and alters the cancer genome organization. To that end, we performed ChIP-seq, RNA-seq, 4C-seq and SIQHiC (Spike-in Quantitative Hi-C) on the U2OS osteosarcoma cell line with tetracycline-inducible MYC. MYC ove...
Source: Genome Research - February 3, 2022 Category: Genetics & Stem Cells Authors: See, Y. X., Chen, K., Fullwood, M. J. Tags: RESEARCH Source Type: research

Cancers, Vol. 11, Pages 1858: FoxO3a as a Positive Prognostic Marker and a Therapeutic Target in Tamoxifen-Resistant Breast Cancer
Conclusions: Altogether, our data indicate that FoxO3a is a key target to be exploited in endocrine-resistant tumors. In this context, LTG, being able to induce FoxO3a, might represent a valid candidate in combination therapy to prevent resistance to tamoxifen in patients at risk.
Source: Cancers - November 24, 2019 Category: Cancer & Oncology Authors: Michele Pellegrino Pietro Rizza Ada Don à Alessandra Nigro Elena Ricci Marco Fiorillo Ida Perrotta Marilena Lanzino Cinzia Giordano Daniela Bonofiglio Rosalinda Bruno Federica Sotgia Michael P. Lisanti Diego Sisci Catia Morelli Tags: Article Source Type: research

Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF- κB activation.
Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation. Acta Pharmacol Sin. 2019 Feb 21;: Authors: Yi Q, Tan FH, Tan JA, Chen XH, Xiao Q, Liu YH, Zhang GP, Luo JD Abstract Minocycline is a tetracycline antibiotic and has been shown to play a protective role in cerebral and myocardial ischemia/reperfusion (I/R). However, the underlying mechanism remains unclear. Herein, we investigated whether monocyte chemotactic protein-induced protein-1 (MCPIP1), a negative regulator of inflammation, was involved in the minocycline-induced card...
Source: Acta Pharmacologica Sinica - February 21, 2019 Category: Drugs & Pharmacology Authors: Yi Q, Tan FH, Tan JA, Chen XH, Xiao Q, Liu YH, Zhang GP, Luo JD Tags: Acta Pharmacol Sin Source Type: research

Lentiviral ‑mediated inducible silencing of TLR4 attenuates neuropathic pain in a rat model of chronic constriction injury.
In conclusion, TLR4 may serve a significant role in neuropathy and the results of the present study provide an inducible lentivirus‑mediated siRNA against TLR4 that may serve as a potential novel strategy to be applied in gene therapy for NP in the future. PMID: 30365084 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 27, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Elucidating the novel BRCA1 function as a non-genomic metabolic restraint in ER-positive breast cancer cell lines.
Authors: Koobotse M, Holly J, Perks C Abstract Within populations carrying the same genetic predisposition, the penetrance of BRCA1 mutations has increased over time. Although linked to changes in lifestyle factors associated with energy metabolism, these observations cannot be explained by the established role of BRCA1 in DNA repair alone. We manipulated BRCA1 expression using tetracycline in the UBR60-bcl2 cell line (which has an inducible, tetracycline-regulated BRCA1 expression) and siRNA in oestrogen receptor(ER)-positive MCF7 and T47D breast cancer cells. Cellular responses to BRCA1 silencing and IGF-I action...
Source: Oncotarget - October 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

P53/PUMA are potential targets that mediate the protection of brain-derived neurotrophic factor (BDNF)/TrkB from etoposide-induced cell death in neuroblastoma (NB)
In this study, we investigated the roles of P53 and BCL2 family members in the protection of BDNF/TrkB from etoposide-induced NB cell death. TB3 and TB8, two tetracycline (TET)-regulated TrkB-expressing NB cell lines, were utilized. The expressions of P53 and BCL2 family members were detected by Western blot or RT-PCR. Transfection of siRNAs was used to knockdown P53 or PUMA. Activated lentiviral was used to over-express PUMA. Cell survival was performed by MTS assay, and the percentage of cell confluence was measured by IncuCyte ZOOM. Our results showed that etoposide treatment induced significant and time-dependent incre...
Source: Apoptosis - June 29, 2018 Category: Molecular Biology Source Type: research

Non-SMC Condensin I Complex, Subunit G (NCAPG) is a Novel Mitotic Gene Required for Hepatocellular Cancer Cell Proliferation and Migration.
Authors: Zhang Q, Su R, Shan C, Gao C, Wu P Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Currently, only chemoembolization and sorafenib have shown survival benefits for advanced HCC. There are major unmet needs in HCC management and the discovery of new therapeutic targets. Here, we identified that NCAPG(non-SMC condensin I complex, subunit G) as a novel mitotic gene required for HCC cell proliferation and migration through siRNA knockdown of a panel of novel overexpressed genes in HCC based on The Cancer Genome Atlas (TCGA) dataset. We found that knockdow...
Source: Oncology Research - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway
Conclusions: Minocycline inhibits HIF-1α-mediated cellular responses and protects BBB integrity through SIRT-3/PHD-2 pathway, proving to be a potential drug for the prevention and treatment of hypoxic brain injuries.
Source: Neuroscience - August 7, 2015 Category: Neuroscience Source Type: research

Abstract 1713: IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis
ConclusionsOur study results demonstrate that IL-24 inhibits lung tumor cell migration and invasion by disrupting the SDF-1/CXCR4 signaling pathway and exhibits enhanced anti-metastatic activity when combined with CXCR4 inhibitors.Citation Format: Janani Panneerselvam, Jiankang Jin, Manish Shanker, Jason Lauderdale, Jonathan Bates, Qi Wang, Daniel Zhao, Stephen Archibald, Timothy Hubin, Rajagopal Ramesh. IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Panneerselvam, J., Jin, J., Shanker, M., Lauderdale, J., Bates, J., Wang, Q., Zhao, D., Archibald, S., Hubin, T., Ramesh, R. Tags: Experimental and Molecular Therapeutics Source Type: research

p16 and Gigaxonin Mediated Ubiquitination of NF{kappa}B Molecular Bases of Disease
The molecular mechanism of p16-mediated senescence in cisplatin-treated cancer cells is not fully understood. Here we show that cisplatin treatment of head and neck cancer cells results in nuclear transport of p16 leading to a molecular modification of NFκB. Chromatin immunoprecipitation assays show that this modification is associated with the inhibition of NFκB interacting with its DNA binding sequences, leading to decreased expression of NFκB-transcribed proteins. LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a tetracycline-inducible GFP-S peptide-NFκB expression system identified g...
Source: Journal of Biological Chemistry - December 11, 2014 Category: Chemistry Authors: Veena, M. S., Wilken, R., Zheng, J.-Y., Gholkar, A., Venkatesan, N., Vira, D., Ahmed, S., Basak, S. K., Dalgard, C. L., Ravichandran, S., Batra, R. K., Kasahara, N., Elashoff, D., Fishbein, M. C., Whitelegge, J. P., Torres, J. Z., Wang, M. B., Srivatsan, Tags: Cell Biology Source Type: research

The involvement of FAK and Src in the invasion of cardiomyocytes by Trypanosoma cruzi.
Abstract The activation of signaling pathways involving protein tyrosine kinases (PTKs) has been demonstrated during Trypanosoma cruzi invasion. Herein, we describe the participation of FAK/Src in the invasion of cardiomyocytes by T. cruzi. The treatment of cardiomyocytes with genistein, a PTK inhibitor, significantly reduced T. cruzi invasion. Also, PP1, a potent Src-family protein inhibitor, and PF573228, a specific FAK inhibitor, also inhibited T. cruzi entry; maximal inhibition was achieved at concentrations of 25μM PP1 (53% inhibition) and 40μM PF573228 (50% inhibition). The suppression of FAK expression in...
Source: Experimental Parasitology - February 25, 2014 Category: Parasitology Authors: de Melo TG, Tucci AR, Nogueira AR, Meirelles MD, Pereira MC Tags: Exp Parasitol Source Type: research

Involvement of CTR1 and ATP7A in Lead (Pb)-induced Copper (Cu) Accumulation in Choroidal Epithelial Cells.
This study investigated the roles of Cu transporter 1 (CTR1) and ATP7A, two Cu transporters, in Pb-induced Cu accumulation in the choroidal epithelial cells. Pb exposure resulted in increased intracellular (64)Cu retention, accompanying with up-regulated CTR1 level. Knockdown of CTR1 using siRNA before Pb exposure diminished the Pb-induced increase of (64)Cu uptake. The expression level of ATP7A was down-regulated following the Pb exposure. ATP7A siRNA knockdown, or PCMB treatment, inhibited the (64)Cu efflux from the cells, while the following additional incubation with Pb failed to further increase the intracellular (64)...
Source: Toxicology Letters - December 5, 2013 Category: Toxicology Authors: Zheng G, Zhang J, Xu Y, Shen X, Song H, Jing J, Luo W, Zheng W, Chen J Tags: Toxicol Lett Source Type: research